ArticleJournal of Alzheimer's disease : JAD2022
No Influence of Age-Related Hearing Loss on Brain Amyloid-β.
Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 13 citations in OpenAlex.
- Alzheimer's disease biomarkers in relation to non-cognitive domains within the intrinsic capacity framework: a narrative review.GeroScience · 2026Review
- Exploring the Relationship Between Hearing Loss and Cognitive Dysfunction from the Perspective of Molecular Mechanisms.Biomolecules · 2026Review
- Hearing Loss Among Older Adults: Epidemiology, Disparities, and Gaps in Research.Annual review of public health · 2026Review
- The Effect of Treating Hearing Loss with Hearing Aids on Plasma Biomarkers of Alzheimer's Disease and Related Dementias.medRxiv : the preprint server for health sciences · 2025Article
- Visual and Auditory Sensory Impairments Differentially Relate with Alzheimer's Pathology.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Relationship between hearing impairment and dementia and cognitive function: a Mendelian randomization study.Alzheimer's research & therapy · 2024Article
- The biphasic impact of apolipoprotein E ε4 allele on age-related hearing loss.Scientific reports · 2024Article
- Age-related hearing loss is not linked to cerebrospinal fluid levels of β-amyloid or p-tau181.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Age-related hearing loss and dementia-related neuropathology: An analysis of the United Kingdom brains for dementia research cohort.Brain pathology (Zurich, Switzerland) · 2023Article
- Hearing, β-Amyloid Deposition and Cognitive Test Performance in Black and White Older Adults: The ARIC-PET Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Hearing loss and its link to cognitive impairment and dementia.Frontiers in dementia · 2023Review
- Considering hearing loss as a modifiable risk factor for dementia.Expert review of neurotherapeutics · 2022Article
- The effect of treating hearing loss with hearing aids on plasma biomarkers of Alzheimer's disease and related dementias.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHearing loss is independently associated with a faster rate of cognitive decline in older adults and has been identified as a modifiable risk factor for dementia. The mechanism for this association is unknown, and there has been limited exploration of potential casual pathology.
objectiveOur objective was to investigate whether there was an association between degree of audiometrically measured hearing loss (HL) and brain amyloid-β (Aβ) in a pre-clinical sample.
methodsParticipants of the Australian Imaging and Biomarker Longitudinal Study (AIBL; n = 143) underwent positron emission tomography (PET) imaging and objective measurement of hearing thresholds within 5 years of imaging, as well as cognitive assessment within 2 years of imaging in this observational cohort study.
resultsWith one exception, study participants who had cognitive assessments within 2 years of their PET imaging (n = 113) were classified as having normal cognition. There was no association between cognitive scores and degree of hearing loss, or between cognitive scores and Aβ load. No association between HL and Aβ load was found once age was controlled for. As previously reported, positive Apolipoprotein E4 (APOE4) carrier status increased the risk of being Aβ positive (p = 0.002).
conclusionDegree of HL was not associated with positive Aβ status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.