Evidence map›Paper›PMID 34806539›Full record

ArticleBioengineered2021

Expression of Cyclin D1 gene in ovarian cancer and effect of silencing its expression on ovarian cancer cells based on the Oncomine database.

Li-Li Quan, Jin-Yang Liu, Li-Xia Qu, Hui La, Hai-Li Wang, Xiao-Xia Chen, Na Wang, Zhen-Zhi Wei

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

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  4. Review
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  10. CENPF promotes the proliferation of renal cell carcinomaTranslational andrology and urology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Li-Li QuanDepartment of Gynecology, Sanmenxia Central Hospital of Henan University of Science and Technology, Sanmenxia, Henan Province, China.
Jin-Yang LiuDepartment of Gynecology, Sanmenxia Central Hospital of Henan University of Science and Technology, Sanmenxia, Henan Province, China.
Li-Xia QuDepartment of Gynecology, Sanmenxia Central Hospital of Henan University of Science and Technology, Sanmenxia, Henan Province, China.
Hui LaDepartment of Gynecology, Sanmenxia Central Hospital of Henan University of Science and Technology, Sanmenxia, Henan Province, China.
Hai-Li WangDepartment of Anesthesiology, Sanmenxia Central Hospital of Henan University of Science and Technology, Sanmenxia, Henan Province, China.
Xiao-Xia ChenDepartment of Gynecology, Sanmenxia Central Hospital of Henan University of Science and Technology, Sanmenxia, Henan Province, China.
Na WangDepartment of Gynecology, Sanmenxia Central Hospital of Henan University of Science and Technology, Sanmenxia, Henan Province, China.
Zhen-Zhi WeiDepartment of Gynecology, Sanmenxia Central Hospital of Henan University of Science and Technology, Sanmenxia, Henan Province, China.
Henan University of Science and Technology · CNXian Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to analyze the expression of Cyclin D1 (CCND1) gene in ovarian cancer and the influence of silencing its expression on ovarian cancer cells based on the Oncomine database. The expression of CCND1 gene in ovarian cancer was analyzed by utilizing the relevant information in different tumors and Oncomine database. The correlation between CCDN1 expression level and prognosis of ovarian cancer was analyzed by the online database Kaplan-Meier (kmplot.com). The expression of CCND1 gene in ovarian cancer and the effect of silencing its expression on cancer cells were analyzed by cell experiments. After mining and comprehensively analyzing 7 studies on the differential expression of CCND1 gene in ovarian cancer tissue and normal ovarian tissue included in the Oncomine database, it was found that the median value of CCND1 gene ranked 218.0 (P = 8.03 × 10

Indexed as

Databases, GeneticGene Expression Regulation, NeoplasticGene SilencingApoptosisCell CycleCell Line, TumorCyclin D1Epithelial CellsFemaleGene Regulatory NetworksHumansOvarian NeoplasmsSurvival RateCCND1 protein, humanCyclin D1Cyclin D1Oncomineovarian cancersilencing

Identifiers

PMID34806539
PMCPMC8810081
OpenAlexW3216826229

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.