Evidence map›Paper›PMID 34806494›Full record

ArticleMolecular pain

Cortical mechanisms in migraine.

Wei Dai, Ren-Hao Liu, Enchao Qiu, Yinglu Liu, Zhiye Chen, Xiaoyan Chen, Ran Ao, Min Zhuo, Shengyuan Yu

Open access · goldAbstract read
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  7. Overlapping pathways of migraine and the endocannabinoid system: Potential therapeutic targets.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Wei DaiDepartment of Neurology, Chinese PLA General Hospital, Beijing, China.ORCID 0000-0002-7015-2531
Ren-Hao LiuCenter for Neuron and Disease, Frontier Institutes of Science and Technology, 12480Xi'an Jiaotong University, Xi'an, China.
Enchao QiuDepartment of Neurology, Chinese PLA General Hospital, Beijing, China.
Yinglu LiuDepartment of Neurology, Chinese PLA General Hospital, Beijing, China.
Zhiye ChenDepartment of Neurology, Chinese PLA General Hospital, Beijing, China.
Xiaoyan ChenDepartment of Neurology, Chinese PLA General Hospital, Beijing, China.
Ran AoDepartment of Neurology, Chinese PLA General Hospital, Beijing, China.
Min ZhuoCenter for Neuron and Disease, Frontier Institutes of Science and Technology, 12480Xi'an Jiaotong University, Xi'an, China.
Shengyuan YuDepartment of Neurology, Chinese PLA General Hospital, Beijing, China.ORCID 0000-0001-8933-088X
Chinese PLA General Hospital · CNUniversity of New Brunswick · CAXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine is the second most prevalent disorder in the world; yet, its underlying mechanisms are still poorly understood. Cumulative studies have revealed pivotal roles of cerebral cortex in the initiation, propagation, and termination of migraine attacks as well as the interictal phase. Investigation of basic mechanisms of the cortex in migraine not only brings insight into the underlying pathophysiology but also provides the basis for designing novel treatments. We aim to summarize the current research literatures and give a brief overview of the cortex and its role in migraine, including the basic structure and function; structural, functional, and biochemical neuroimaging; migraine-related genes; and theories related to cortex in migraine pathophysiology. We propose that long-term plasticity of synaptic transmission in the cortex encodes migraine.

Indexed as

Cortical Spreading DepressionMigraine DisordersCerebral CortexHumansSynaptic Transmissioncerebral cortexcortical spreading depressionlong-term potentiationmigrainepathophysiology

Identifiers

PMID34806494
PMCPMC8606910
OpenAlexW3216097047

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.