Observational studyChronic respiratory disease
The association of blood urea nitrogen levels upon emergency admission with mortality in acute exacerbation of chronic obstructive pulmonary disease.
Observational study in Chronic respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 42 citations in OpenAlex.
- Prognostic Value of the Blood Urea Nitrogen-to-Albumin Ratio (BAR) for Long-Term Survival Outcomes Among ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention.Reviews in cardiovascular medicine · 2026Article
- Correlation between urea-to-creatinine ratio and poor prognosis of intensive care unit patients with chronic obstructive pulmonary disease: a study based on the MIMIC-IV database.BMC pulmonary medicine · 2026Article
- Development and Internal Validation of a Multivariable Prognostic Model for in-Hospital Mortality in Critically Ill Patients with Acute Exacerbation of COPD.International journal of chronic obstructive pulmonary disease · 2026Observational
- Association between blood urea nitrogen-to-albumin ratio and mortality in ICU patients with chronic obstructive pulmonary disease: data from the MIMIC IV database.BMC geriatrics · 2025Article
- Lactate Dehydrogenase/Albumin to Urea Ratio: A Novel Prognostic Indicator for Adverse Outcomes in Patients With Severe Fever With Thrombocytopenia Syndrome.Journal of medical virology · 2025Article
- Predictors of Poor Pneumonia Outcomes in Older Adults: A Multicentered Follow-Up Study.Health science reports · 2025Article
- Construction and Validation of an Early Warning Model for Predicting the 28-Day Mortality in Sepsis Patients with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Article
- Association Between Blood Urea Nitrogen to Serum Albumin Ratio and Mortality in Critically Ill Patients With Chronic Obstructive Pulmonary Disease: A Retrospective Study.International journal of chronic obstructive pulmonary disease · 2025Article
- The predictive power of albumin-based composite indicators for mortality in patients with aspiration pneumonia.Northern clinics of Istanbul · 2025Article
- Blood urea nitrogen-to-albumin ratio independently predicts 30-day mortality in acute respiratory failure patients: a retrospective cohort study.Journal of thoracic disease · 2024Article
- Blood Urea Nitrogen-to-Serum Albumin Ratio Predicts Fatal Outcomes in Severe Fever with Thrombocytopenia Syndrome Patients.The American journal of tropical medicine and hygiene · 2024Article
- An International Validation of the "DECAF Score" to Predict Disease Severity and Hospital Mortality in Acute Exacerbation of COPD in the UAE.Hospital pharmacy · 2024Article
- Association between admission heart rate and in-hospital mortality in patients with acute exacerbation of chronic obstructive pulmonary disease and respiratory failure: a retrospective cohort study.BMC pulmonary medicine · 2024Article
- Blood Urea Nitrogen-to-Albumin Ratio May Predict Mortality in Patients with Traumatic Brain Injury from the MIMIC Database: A Retrospective Study.Bioengineering (Basel, Switzerland) · 2024Article
- Use of the Serum Level of Cholinesterase as a Prognostic Marker of Nonfatal Clinical Outcomes in Patients Hospitalized with Acute Exacerbations of Chronic Obstructive Pulmonary Disease.Canadian respiratory journal · 2024Article
- Development and Validation of an In-Hospital Mortality Prediction Model for Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2024Article
- The Relationship Between Blood Urea Nitrogen to Creatinine Ratio and Severe Acute Exacerbation of COPD Patients: A Propensity Score Matching Study.International journal of chronic obstructive pulmonary disease · 2024Article
- Article
- A Nomogram Model for Prediction of Mortality Risk of Patients with Dangerous Upper Gastrointestinal Bleeding: A Two-center Retrospective Study.Current medical science · 2023Article
- Elevated BUN Upon Admission as a Predictor of in-Hospital Mortality Among Patients with Acute Exacerbation of COPD: A Secondary Analysis of Multicenter Cohort Study.International journal of chronic obstructive pulmonary disease · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeHigh blood urea nitrogen (BUN) is associated with an elevated risk of mortality in various diseases, such as heart failure and pneumonia. Heart failure and pneumonia are common comorbidities of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, data on the relationship of BUN levels with mortality in patients with AECOPD are sparse. The purpose of this study was to evaluate the correlation between BUN level and in-hospital mortality in a cohort of patients with AECOPD who presented at the emergency department (ED).
methodsA total of 842 patients with AECOPD were enrolled in the retrospective observational study from January 2018 to September 2020. The outcome was all-cause in-hospital mortality. Receiver operating characteristic (ROC) curve analysis and logistic regression models were performed to evaluate the association of BUN levels with in-hospital mortality in patients with AECOPD. Propensity score matching was used to assemble a cohort of patients with similar baseline characteristics, and logistic regression models were also performed in the propensity score matching cohort.
resultsDuring hospitalization, 26 patients (3.09%) died from all causes, 142 patients (16.86%) needed invasive ventilation, and 190 patients (22.57%) were admitted to the ICU. The mean level of blood urea nitrogen was 7.5 ± 4.5 mmol/L. Patients in the hospital non-survivor group had higher BUN levels (13.48 ± 9.62 mmol/L vs. 7.35 ± 4.14 mmol/L,
conclusionsIncreased BUN level at ED admission is associated with hospital mortality in patients with AECOPD who present at the ED. The level of 7.63 mmol/L can be used as a cutoff value for critical stratification.
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