Evidence map›Paper›PMID 34806426›Full record

Trial reportAmerican journal of physiology. Endocrinology and metabolism2022

Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function.

Sanna Laurila, Eleni Rebelos, Minna Lahesmaa, Lihua Sun, Katharina Schnabl, Tia-Mari Peltomaa, Riku Klén, Mueez U-Din, Miikka-Juhani Honka, Olli Eskola and 5 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of physiology. Endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03290846 (Secretin Increases Glucose Uptake in Human Brown Adipose Tissue and Induces Satiation.), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03290846 phase2 / phase3completednot on this map

Secretin Increases Glucose Uptake in Human Brown Adipose Tissue and Induces Satiation.

TypeinterventionalSponsorTurku University HospitalRan2016 to 2019Enrolled23ConditionsObesityArmsSecretin Human, Saline Solution, Cold exposure
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Secretin: a hormone for HCOPflugers Archiv : European journal of physiology · 2024
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Sanna LaurilaTurku PET Centre, University of Turku, Turku, Finland.ORCID 0000-0002-1170-5079
Eleni RebelosTurku PET Centre, University of Turku, Turku, Finland.
Minna LahesmaaTurku PET Centre, University of Turku, Turku, Finland.
Lihua SunTurku PET Centre, University of Turku, Turku, Finland.
Katharina SchnablChair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.ORCID 0000-0001-7732-8934
Tia-Mari PeltomaaTurku PET Centre, University of Turku, Turku, Finland.
Riku KlénTurku PET Centre, University of Turku, Turku, Finland.
Mueez U-DinTurku PET Centre, Turku University Hospital, Turku, Finland.
Miikka-Juhani HonkaTurku PET Centre, University of Turku, Turku, Finland.ORCID 0000-0001-9875-5863
Olli EskolaTurku PET Centre, University of Turku, Turku, Finland.
Anna K KirjavainenTurku PET Centre, University of Turku, Turku, Finland.
Lauri NummenmaaTurku PET Centre, University of Turku, Turku, Finland.
Martin KlingensporChair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.ORCID 0000-0002-4502-6664
Kirsi A VirtanenTurku PET Centre, Turku University Hospital, Turku, Finland.
Pirjo NuutilaTurku PET Centre, University of Turku, Turku, Finland.ORCID 0000-0001-9597-338X
University of Turku · FIFresenius (Germany) · DETurku University Hospital · FIUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cardiac benefits of gastrointestinal hormones have been of interest in recent years. The aim of this study was to explore the myocardial and renal effects of the gastrointestinal hormone secretin in the GUTBAT trial (NCT03290846). A placebo-controlled crossover study was conducted on 15 healthy males in fasting conditions, where subjects were blinded to the intervention. Myocardial glucose uptake was measured with [

Indexed as

AdolescentAdultAgedCross-Over StudiesFastingFluorodeoxyglucose F18Glomerular Filtration RateGlucoseHealthy VolunteersHeartHumansInfusions, IntravenousKidneyMaleMiddle AgedMyocardiumFluorodeoxyglucose F18GlucoseRadiopharmaceuticalsSecretingastrointestinal hormonekidney functionmyocardial metabolismsecretin

Identifiers

PMID34806426
PMCPMC8791786
OpenAlexW3215303866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.