Evidence map›Paper›PMID 34806400›Full record

ReviewAntioxidants & redox signaling2022

Tetrahydrobiopterin in Cell Function and Death Mechanisms.

Jeannette Vasquez-Vivar, Zhongjie Shi, Sidhartha Tan

Open access · greenAbstract readReview
In one paragraph

Review in Antioxidants & redox signaling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Role of Ferroptosis on Lung Epithelial Cells in Disease Progression and Treatment: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Mechanisms of Vitamins Inhibiting Ferroptosis.Antioxidants (Basel, Switzerland) · 2024
    Review
  14. Review
  15. Ferroptosis-A Shared Mechanism for Parkinson's Disease and Type 2 Diabetes.International journal of molecular sciences · 2024
    Review
  16. Current Progress of Ferroptosis Study in Hepatocellular Carcinoma.International journal of biological sciences · 2024
    Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jeannette Vasquez-VivarRedox Biology Program, Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Zhongjie ShiDepartment of Pediatrics, Wayne State University, Detroit, Michigan, USA.
Sidhartha TanDepartment of Pediatrics, Wayne State University, Detroit, Michigan, USA.ORCID 0000-0003-2382-729X
Wayne State University · USMedical College of Wisconsin · US

Funding

Probing Role of Tetrahydrobiopterin in Cerebral Palsy by Using Transgenic RabbitsR01NS117146 · NINDS · WAYNE STATE UNIVERSITY · PI TAN, SIDHARTHA, VASQUEZ VIVAR, JEANNETTE M. · 2021 to 2025
$3.1M
Neuroprotection by nNOS inhibitors in perinatal hypoxia-ischemiaR01NS114972 · NINDS · WAYNE STATE UNIVERSITY · PI TAN, SIDHARTHA · 2020 to 2024
$3.1M
Tetrahydrobiopterin in Fetal Hypoxic Brain InjuryR01NS081936 · NINDS · WAYNE STATE UNIVERSITY · PI TAN, SIDHARTHA, VASQUEZ VIVAR, JEANNETTE M. · 2013 to 2017
$2.0M
NINDS NIH HHS R01 NS081936NINDS NIH HHS R01 NS114972NINDS NIH HHS R01 NS117146
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BiopterinsGTP CyclohydrolaseNitric OxideOxidation-ReductionBiopterinsGTP CyclohydrolaseNitric Oxidesapropterinapoptosisferroptosisnecroptosisnitric oxideoxidantssepiapterin

Identifiers

PMID34806400
PMCPMC9293684
OpenAlexW3215189224

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.