Evidence map›Paper›PMID 34806324›Full record

ArticlePhysiological reports2021

Phosphorylation of Lamin A/C at serine 22 modulates Na

Michael A Olaopa, Tomohiko Ai, Bo Chao, Xiangshu Xiao, Matteo Vatta, Beth A Habecker

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Post-Translational Modification of Lamins: Mechanisms and Functions.Frontiers in cell and developmental biology · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Michael A OlaopaDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.
Tomohiko AiKrannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Bo ChaoDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.
Xiangshu XiaoDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.
Matteo VattaKrannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Beth A HabeckerDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0002-4658-8730
Oregon Health & Science University · USIndiana University School of MedicineJuntendo University · JP

Funding

Neurotrophins and post-infarct plasticity in cardiac sympathetic neuronsR01HL093056 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BETH A HABECKER · 2009 to 2026
$7.9M
Chemical Modulators of Nuclear LaminsR01CA211866 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI XIAO, XIANGSHU · 2017 to 2022
$2.2M
NCI NIH HHS R01 CA211866NHLBI NIH HHS R01 HL093056
6 · The paper itself

Abstract

Variants in the LMNA gene, which encodes for Lamin A/C, are associated with cardiac conduction disease (CCD). We previously reported that Lamin A/C variants p.R545H and p.A287Lfs*193, which were identified in CCD patients, decreased peak I

Indexed as

Cardiac Conduction System DiseaseHEK293 CellsHumansLamin Type AMutationMutation, MissenseNAV1.5 Voltage-Gated Sodium ChannelPatch-Clamp TechniquesPhosphorylationLamin Type ALMNA protein, humanNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humancardiac conduction diseaseLamin phosphorylationNav1.5

Identifiers

PMID34806324
PMCPMC8606869
OpenAlexW3217764925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.