Evidence map›Paper›PMID 34806323›Full record

ArticleObesity (Silver Spring, Md.)2022

The vaginal microbiome in women of reproductive age with healthy weight versus overweight/obesity.

Natalie G Allen, Laahirie Edupuganti, David J Edwards, Nicole R Jimenez, Gregory A Buck, Kimberly K Jefferson, Jerome F Strauss, Vaginal Microbiome Consortium, Edmond P Wickham, Jennifer M Fettweis

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Microbiome, Human Papillomavirus and Cervical Carcinogenesis.Current topics in microbiology and immunology · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Observational
  16. Scoping Review of Microbiota Dysbiosis and Risk of Preeclampsia.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Natalie G AllenDepartment of Pediatrics, Division of Endocrinology and Diabetes, Penn State Health, Hershey, Pennsylvania, USA.ORCID 0000-0002-5515-1469
Laahirie EdupugantiDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
David J EdwardsDepartment of Statistical Sciences & Operations Research, Virginia Commonwealth University, Richmond, Virginia, USA.
Nicole R JimenezDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Gregory A BuckDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Kimberly K JeffersonDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Jerome F StraussDepartment of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia, USA.
Vaginal Microbiome Consortium
Edmond P WickhamDepartment of Pediatrics, Division of Endocrinology, Diabetes, and Metabolism, Virginia Commonwealth University, Richmond, Virginia, USA.
Jennifer M FettweisDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.

Funding

Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
A Multi-'omic Analysis of the Vaginal Microbiome during PregnancyU54HD080784 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN, JEFFERSON, KIMBERLY KAY · 2014 to 2015
$8.2M
The Vaginal Microbiome: Disease, Genetics and the EnvironmentUH3AI083263 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN · 2010 to 2012
$6.8M
Virginia Commonwealth University Initiative for Maximizing Student DevelopmentR25GM090084 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI AKBARALI, HAMID I, LLOYD, JOYCE A. · 2010 to 2022
$5.2M
Transmission of Maternal Vaginal and Gut Microbiome and Obesity Risk in OffspringR21HD092965 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI FETTWEIS, JENNIFER MAUREEN, WICKHAM, EDMOND PRYCE · 2017 to 2018
$416k
Foundation for the National Institutes of Health R21HD092965Foundation for the National Institutes of Health R25GM090084Foundation for the National Institutes of Health U54HD080784Foundation for the National Institutes of Health UH3AI083263NCATS NIH HHS UL1 TR002649NIAID NIH HHS UH3 AI083263NICHD NIH HHS R21 HD092965NICHD NIH HHS U54 HD080784NIGMS NIH HHS R25 GM090084
6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate the differences between the vaginal microbiome of reproductive-aged women with overweight and obesity (Ow/Ob) compared with healthy weight (HW).

methodsIn this case-control study, a cohort of 367 nonpregnant women (18 to 40 years) with Ow/Ob (BMI ≥25 kg/m

resultsMean age and BMI of Ow/Ob and HW groups were 26.8 versus 26.7 years and 37.0 versus 22.1 kg/m

conclusionsThe vaginal microbiome differs in reproductive-aged women with Ow/Ob compared with women with HW, with increased alpha diversity and decreased predominance of Lactobacillus. Observed differences in the vaginal microbiome may partially explain differences in preterm birth and bacterial vaginosis risk between these populations.

Indexed as

MicrobiotaPremature BirthAdultCase-Control StudiesFemaleHumansInfant, NewbornObesityOverweightRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID34806323
PMCPMC9070090

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.