ArticleJournal of clinical hypertension (Greenwich, Conn.)2021
Effect of chronic kidney disease on the association between hyperuricemia and new-onset hypertension in the general Japanese population: ISSA-CKD study.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 11 citations in OpenAlex.
- Non-fasting and fasting serum triglyceride concentrations and new-onset hyperuricemia in the general Japanese population: ISSA-CKD study.Scientific reports · 2025Article
- Relationship between abdominal circumference and the incidence of hyperuricemia in the general Japanese population.Scientific reports · 2024Article
- Observational
- Association between serum uric acid levels and achievement of target blood pressure among Japanese community residents with hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Identification of risk factors for hypertension in overweight and obese people and analysis of risk factor interactions: an R-based analysis.Frontiers in cardiovascular medicine · 2023Article
- Reduced Incidence of Stroke in Patients with Gout Using Benzbromarone.Journal of personalized medicine · 2022Article
- Effect of chronic kidney disease on the association between hyperuricemia and new-onset hypertension in the general Japanese population: ISSA-CKD study.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Link between hyperuricemia, renal dysfunction, and hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
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20 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We aimed to investigate the association between serum uric acid (SUA) level and development of hypertension as well as the interaction effect of chronic kidney disease (CKD) on this relationship in the general Japanese population. We included 7895 participants aged ≥30 years from the ISSA-CKD study, a population-based retrospective cohort study that used annual health check-up data of residents from Iki Island, Japan. After the exclusion of 1881 with l < 1-year follow-up, 2812 with hypertension at baseline, and 165 with missing information on SUA, a total of 3037 participants were enrolled in this analysis. Participants were divided into four groups according to the quartiles of SUA level at baseline, and multivariable-adjusted hazard ratios for new-onset hypertension were calculated. Stratified analyses were performed for each subgroup (defined by sex, age, alcohol intake, and CKD) to assess the interaction effects. During a mean follow-up period of 4.4 years, 943 participants developed hypertension. The first quartile group was set as the reference group, and the multivariable-adjusted hazard ratios (95% confidence interval) for new-onset hypertension were 1.11 (0.90-1.36) in the second quartile, 1.25 (1.02-1.54) in the third quartile, and 1.35 (1.07-1.70) in the fourth quartile compared with those in the reference group (p = .007 for trend). The stratified analyses showed that the association between SUA and hypertension was significantly stronger in participants with CKD than in those without CKD (p = .035 for interaction). SUA level is an independent risk factor for new-onset hypertension. This tendency was significantly stronger in participants with CKD.
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