Evidence map›Paper›PMID 34806143›Full record

ArticleInternational journal of computer assisted radiology and surgery2021

Virtual embolization for treatment support of intracranial AVMs using an interactive desktop and VR application.

Ulrike Sprengel, Patrick Saalfeld, Janneck Stahl, Sarah Mittenentzwei, Moritz Drittel, Benjamin Behrendt, Naoki Kaneko, Daniel Behme, Philipp Berg, Bernhard Preim and 1 more

Abstract read
In one paragraph

Article in International journal of computer assisted radiology and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ulrike SprengelDepartment of Simulation and Graphics, Otto-von-Guericke University Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany. ulrike.sprengel@st.ovgu.de.ORCID http://orcid.org/0000-0003-2904-5360
Patrick SaalfeldDepartment of Simulation and Graphics, Otto-von-Guericke University Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany.
Janneck StahlDepartment of Fluid Dynamics and Technical Flows, Otto-von-Guericke University Magdeburg, Forschungscampus STIMULATE, Magdeburg, Germany.
Sarah MittenentzweiDepartment of Simulation and Graphics, Otto-von-Guericke University Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany.
Moritz DrittelDepartment of Simulation and Graphics, Otto-von-Guericke University Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany.
Benjamin BehrendtDepartment of Simulation and Graphics, Otto-von-Guericke University Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany.
Naoki KanekoDepartment of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, USA.
Daniel BehmeDepartment of Neuroradiology, University Hospital Magdeburg, Magdeburg, Germany.
Philipp BergDepartment of Fluid Dynamics and Technical Flows, Otto-von-Guericke University Magdeburg, Forschungscampus STIMULATE, Magdeburg, Germany.
Bernhard PreimDepartment of Simulation and Graphics, Otto-von-Guericke University Magdeburg, Universitätsplatz 2, 39106, Magdeburg, Germany.
Sylvia SaalfeldDepartment of Simulation and Graphics, Otto-von-Guericke University Magdeburg, Forschungscampus STIMULATE, Magdeburg, Germany.ORCID http://orcid.org/0000-0002-7002-7917

Funding

Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659Ministerium für Wissenschaft und Wirtschaft, Land Sachsen-Anhalt 13GW0473A
6 · The paper itself

Abstract

purposeThe treatment of intracranial arteriovenous malformations (AVM) is challenging due to their complex anatomy. For this vessel pathology, arteries are directly linked to veins without a capillary bed in between. For endovascular treatment, embolization is carried out, where the arteries that supply the AVM are consecutively blocked. A virtual embolization could support the medical expert in treatment planning.

methodWe designed and implemented an immersive VR application that allows the visualization of the simulated blood flow by displaying millions of particles. Furthermore, the user can interactively block or unblock arteries that supply the AVM and analyze the altered blood flow based on pre-computed simulations.

resultsIn a pilot study, the application was successfully adapted to three patient-specific cases. We performed a qualitative evaluation with two experienced neuroradiologist who regularly conduct AVM embolizations. The feature of virtually blocking or unblocking feeders was rated highly beneficial, and a desire for the inclusion of quantitative information was formulated.

conclusionThe presented application allows for virtual embolization and interactive blood flow visualization in an immersive virtual reality environment. It could serve as useful addition for treatment planning and education in clinical practice, supporting the understanding of AVM topology as well as understanding the influence of the AVM's feeding arteries.

Indexed as

Embolization, TherapeuticIntracranial Arteriovenous MalformationsVirtual RealityHemodynamicsHumansPilot ProjectsAVMEmbolizationVR

Identifiers

PMID34806143
PMCPMC8616893

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.