Evidence map›Paper›PMID 34806132›Full record

ArticleJournal of assisted reproduction and genetics2021

Body mass index, not race, may be associated with an alteration in early embryo morphokinetics during in vitro fertilization.

Luce A Kassi, Dana B McQueen, Dana Kimelman, Rafael Confino, Chen Yeh, Anne Hutchinson, Tarun Jain, Christina Boots, John Zhang, Jaclyn Steinmiller and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Luce A KassiDepartment of Obstetrics and Gynecology, Northwestern University, 676 N Saint Clair, Suite 2310, 250 E. Superior Street, Chicago, IL, 60611, USA.
Dana B McQueenDepartment of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, USA.
Dana KimelmanCentro de Esterilidad Montevideo, Uruguay, Alumni Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Rafael ConfinoDepartment of Obstetrics and Gynecology, Northwestern University, 676 N Saint Clair, Suite 2310, 250 E. Superior Street, Chicago, IL, 60611, USA.
Chen YehDivision of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Anne HutchinsonDepartment of Obstetrics and Gynecology, Northwestern University, 676 N Saint Clair, Suite 2310, 250 E. Superior Street, Chicago, IL, 60611, USA.
Tarun JainDepartment of Obstetrics and Gynecology, Northwestern University, 676 N Saint Clair, Suite 2310, 250 E. Superior Street, Chicago, IL, 60611, USA.
Christina BootsDepartment of Obstetrics and Gynecology, Northwestern University, 676 N Saint Clair, Suite 2310, 250 E. Superior Street, Chicago, IL, 60611, USA.
John ZhangDepartment of Obstetrics and Gynecology, Northwestern University, 676 N Saint Clair, Suite 2310, 250 E. Superior Street, Chicago, IL, 60611, USA.
Jaclyn SteinmillerDepartment of Obstetrics and Gynecology, Northwestern University, 676 N Saint Clair, Suite 2310, 250 E. Superior Street, Chicago, IL, 60611, USA.
Mary Ellen PavoneDepartment of Obstetrics and Gynecology, Northwestern University, 676 N Saint Clair, Suite 2310, 250 E. Superior Street, Chicago, IL, 60611, USA. m-pavone@northwestern.edu.ORCID http://orcid.org/0000-0002-4181-5543

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
NCATS NIH HHS UL1 TR001422
6 · The paper itself

Abstract

objectiveTo assess the relationship between maternal body mass index (BMI) and embryo morphokinetics on time-lapse microscopy (TLM).

designRetrospective cohort study.

methodsAll IVF cycles between June 2015 and April 2017 were reviewed. Female BMI prior to egg retrieval was collected through chart review. BMI (kg/m

resultsA total of 2150 embryos from 589 IVF cycles were reviewed and included in the analysis. Classification based on BMI was as follows: underweight (N = 56), normal weight (N = 1252), overweight (N = 502), and obese (N = 340). After adjusting for race and use of intracytoplasmic sperm injection, the mean time to the 8-cell stage in the underweight group was 4.3 (95% CI: - 8.31, - 0.21) h less than in the normal weight group (P = 0.025) and 4.6 (95% CI: - 8.8, - 0.21) h less than in the obese group (p = 0.022). No significant difference was noted between race and TLM after controlling for possible confounders.

conclusionsEmbryos from underweight women were demonstrated to have a faster time to the 8-cell stage than normal weight or obese women. No significant difference was noted for race. This study demonstrates that weight can be a factor contributing to embryo development as observed with TLM.

Indexed as

AdultBlastocystBody Mass IndexEmbryonic DevelopmentEmbryo TransferFemaleFertilization in VitroHumansLive BirthObesityOverweightPregnancyRetrospective StudiesSperm Injections, IntracytoplasmicTime-Lapse ImagingBody mass indexEmbryo morphokineticsIn vitro fertilizationIVFRacial disparitiesTime-lapse imaging

Identifiers

PMID34806132
PMCPMC8666401

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.