Evidence map›Paper›PMID 34806129›Full record

ArticleJournal of neurology2022

Causes of symptom dissatisfaction in patients with generalized myasthenia gravis.

Linda Kahr Andersen, Anna Sofie Jakobsson, Karoline Lolk Revsbech, John Vissing

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In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Linda Kahr Andersen *Copenhagen Neuromuscular Center, Department of Neurology, Copenhagen University Hospital, Section 8077, Rigshospitalet, Inge Lehmanns Vej 8, 2100, Copenhagen, Denmark. linda.kahr.andersen@regionh.dk.ORCID http://orcid.org/0000-0002-4780-7739
Anna Sofie Jakobsson *Copenhagen Neuromuscular Center, Department of Neurology, Copenhagen University Hospital, Section 8077, Rigshospitalet, Inge Lehmanns Vej 8, 2100, Copenhagen, Denmark.
Karoline Lolk RevsbechCopenhagen Neuromuscular Center, Department of Neurology, Copenhagen University Hospital, Section 8077, Rigshospitalet, Inge Lehmanns Vej 8, 2100, Copenhagen, Denmark.
John VissingCopenhagen Neuromuscular Center, Department of Neurology, Copenhagen University Hospital, Section 8077, Rigshospitalet, Inge Lehmanns Vej 8, 2100, Copenhagen, Denmark.
University of Copenhagen · DKCopenhagen University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatient-centered assessments have attracted increasing attention in the last decade in clinics and research. The purpose of this study was to examine the association between patients' satisfaction with symptoms and several disease-specific and generic outcome measures in 100 patients with generalized myasthenia gravis (gMG).

methodsIn this cross-sectional study, patients with gMG followed at the Copenhagen Neuromuscular Center from October 2019 to June 2020 participated in one test. The patients completed commonly used MG-specific outcome measures and generic questionnaires for depression (Major Depression Inventory), comorbidities (Charlson Comorbidity Index), fatigue (Multidimensional Fatigue Inventory), overall health state (EQ-5D-3L), and satisfaction with MG treatment. The analyses were anchored in the Patient Acceptable Symptom State (PASS).

resultsN = 190 patients were screened for the study, and 100 patients were included. One-third of the patients reported dissatisfaction (negative PASS status) with the current symptom state. Increasing MG symptoms, fatigue, depression, low MG-related quality of life, and shorter disease duration were associated with negative PASS status. Age, sex, BMI, MG treatment, and comorbidity did not influence PASS status.

conclusionsThis study shows that dissatisfaction with the current symptom level is high in patients with gMG and that dissatisfaction is associated with disease severity, disease length, depression, fatigue, and lower MG-related quality of life. The results emphasize the importance of a patient-centered approach to MG treatment to optimize patient satisfaction. The PASS question was useful in this study to investigate the causes of symptom dissatisfaction in gMG.

Indexed as

Myasthenia GravisQuality of LifeCross-Sectional StudiesFatigueHumansPatient SatisfactionDepressionFatigueMyasthenia gravisPatient acceptance of health carePatient outcome assessment

Identifiers

PMID34806129
OpenAlexW3216832866

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.