ReviewInternational journal of cardiology. Cardiovascular risk and prevention2021
Hemodynamic stress and microscopic remodeling.
Review in International journal of cardiology. Cardiovascular risk and prevention, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Aortic Stenosis as a Mechanical Stressor and Tissue Energetics: Consistent Clue with Hypertensive Stress Septal Sign.Journal of clinical medicine · 2026Review
- Takotsubo Cardiomyopathy and Stressed Heart Morphology: Molecular, Hemodynamic, and Imaging Intersections.Journal of clinical medicine · 2025Review
- Stress Septal Sign (Triple S) Preexists in Hypertensive Hearts and Clarifies Critical Diagnostic Strategies.Journal of clinical medicine · 2025Review
- Developmental and Evolutionary Heart Adaptations Through Structure-Function Relationships.Journal of cardiovascular development and disease · 2025Review
- Sudden-onset gastrointestinal bleeding in a young adult: diagnostic and therapeutic challenges of a Dieulafoy's lesion in the jejunum.Surgical case reports · 2024Article
- Stress and Heart in Remodeling Process: Multiple Stressors at the Same Time Kill.Journal of clinical medicine · 2024Review
- Energetics of Cardiac Blood Flow in Hypertrophic Cardiomyopathy through Individualized Computational Modeling.Journal of cardiovascular development and disease · 2023Article
- It Is Time to Focus on "Segmental Remodeling" with Validated Biomarkers as "Stressed Heart Morphology" in Prevention of Heart Failure.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroudHeart responds to physiologic and pathologic conditions and sympathetic drive plays an important role. It has been documented that LV base is more dominantly affected by sympathetic drive compared to the other regions. LV base is more dominantly exposed to wall stress in the initial period of remodeling due to pressure-overload, since LV cavity is the largest at base. Basal septal hypertrophy (BSH) in cross-sectional data is associated with the early phase of hypertensive heart disease. BSH was confirmed by 3rd generation microscopic ultrasound in small animals. BSH as the closest location to increased afterload could be detected in variety of stress stimuli and result in a huge septal hypertrophy in advance cases possibly related to earlier exposure of hemodynamic stress to septal wall.
conclusionEffective geometric and functional evaluation of initial remodeling due to hemodynamic stress is important according to both human and animal data. These findings possibly contribute to early recognition of adaptive phase of hypertensive remodeling and more effective management in a timely fashion.
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Registered trials
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