ArticleThe Lancet regional health. Europe2021
Pregnancy, delivery and neonatal complications in women with schizophrenia: a national population-based cohort study.
Article in The Lancet regional health. Europe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 6 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Association of bipolar disorder and schizophrenia in women with risk of gestational diabetes: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- The prevalence of mental health-related multimorbidity during pregnancy: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Neurobiological insights into perinatal depression: a multi-dimensional integration of brain structure, function, and metabolism.Frontiers in psychiatry · 2026Pooled it
- Pooled it
- Modified electroconvulsive therapy for perinatal depression: scoping review.Frontiers in psychiatry · 2025Pooled it
- Schizophrenia pregnancies should be given greater health priority in the global health agenda: results from a large-scale meta-analysis of 43,611 deliveries of women with schizophrenia and 40,948,272 controls.Molecular psychiatry · 2022Pooled it
- The impact of mental health disorders in pregnancy on obstetric and neonatal outcomes: A narrative review.Brain, behavior, & immunity - health · 2026Review
- Association Between Maternal Genome-Wide Polygenic Scores for Psychiatric and Neurodevelopmental Disorders and Adverse Perinatal Events: A Danish Population-Based Study.Biological psychiatry global open science · 2026Article
- Effectiveness of Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms During Pregnancy by Using Real-World Data: Retrospective Cohort Study.JMIR mHealth and uHealth · 2025Article
- Antipsychotic continuation during pregnancy and risk of postpartum relapse in women with schizophrenia: nationwide register-based study.The British journal of psychiatry : the journal of mental science · 2025Article
- Global Burden of Schizophrenia Among Women of Reproductive Age from 1990 to 2021: Trends, Inequalities, and Projections to 2040.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Changed expression of placental transporters and disrupted epigenetic patterns in a rat model of schizophrenia.Frontiers in pharmacology · 2025Article
- Genetically Informed Study Highlights Income-Independent Effect of Schizophrenia Liability on Mental and Physical Health.Schizophrenia bulletin · 2024Article
- Accelerating adverse pregnancy outcomes research amidst rising medication use: parallel retrospective cohort analyses for signal prioritization.BMC medicine · 2024Article
- The impact of hospital saturation on non-COVID-19 hospital mortality during the pandemic in France: a national population-based cohort study.BMC public health · 2024Article
- Teenage pregnancy: focus on people with mental disorders.Frontiers in psychiatry · 2024Article
- Ethical challenges in the treatment of psychotic pregnancy denial.Frontiers in psychiatry · 2024Review
- [Psychopharmacotherapy during pregnancy and breastfeeding-Part I: focus on pregnancy : Support options by using therapeutic drug monitoring].Der Nervenarzt · 2023Review
- Monitoring the Effectiveness of Treatment in Women with Schizophrenia: New Specialized Cooperative Approaches.Brain sciences · 2023Review
- Reducing Health Inequalities in Individuals with Severe Mental Disorders: Harnessing Real-World Data and Patient-Reported Measures.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExisting studies evaluating the association between schizophrenia and complications associated with pregnancy, delivery and neonatal outcomes are based on data prior to 2014 and have reported heterogeneous results. The objective of our study was to determine whether pregnant women with schizophrenia were at increased risk of pregnancy, delivery and neonatal complications compared with women without severe mental disorders.
methodsWe performed a population-based cohort study of all singleton deliveries in France between Jan. 1, 2015, and Dec. 31, 2019. We divided this population into cases (
findingsOver 5 years, 3,667,461 singleton deliveries were identified, of which 3,108 occurred in women with schizophrenia. Compared to controls, women with schizophrenia were found to be older; have more frequent smoking, alcohol and substance addictions; suffer from obesity, diabetes and chronic obstructive pulmonary disease; and often be hospitalized in tertiary maternity hospitals. Compared to matched controls, women with schizophrenia had more pregnancy complications (adjusted OR=1.41[95%CI 1.31-1.51]) (
interpretationOur results highlight the importance of health disparities between pregnant women with and without schizophrenia, as well as in their newborns. Our study calls for health policy interventions during and before pregnancy, including proportionate intensified care to the level of needs, effective case management and preventive and social determinant approaches.
fundingNo funding.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.