ArticleThe Lancet regional health. Europe2021
Association of maternal pre-pregnancy BMI and breastfeeding with NAFLD in young adults: a parental negative control study.
Article in The Lancet regional health. Europe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Metabolic dysfunction-associated steatotic liver disease and pregnancy.The Journal of clinical investigation · 2025Review
- Associations of infant feeding practices with abdominal and hepatic fat measures in childhood in the longitudinal Healthy Start Study.The American journal of clinical nutrition · 2024Article
- Determinants of non-alcoholic fatty liver disease in young people: Maternal, neonatal, and adolescent factors.PloS one · 2024Article
- High maternal adiposity during pregnancy programs an imbalance in the lipidome and predisposes to diet-induced hepatosteatosis in the offspring.Bioscience reports · 2023Article
- Nonalcoholic liver disease: Epidemiology, risk factors, natural history, and management strategies.Annals of the New York Academy of Sciences · 2023Review
- Prevalence and associated factors of metabolic-associated fatty liver disease in overweight Finnish children and adolescents.Frontiers in endocrinology · 2023Article
- Pregnancy and Metabolic-associated Fatty Liver Disease: A Clinical Update.Journal of clinical and translational hepatology · 2022Review
- Combination Treatment with Hydroxytyrosol and Vitamin E Improves NAFLD-Related Fibrosis.Nutrients · 2022Article
- Relationship between MASLD and women's health: A review.Women's health (London, England)Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe importance of the maternal-infant dyad in the genesis of nonalcoholic fatty liver disease (NAFLD) is of increasing interest. The Avon Longitudinal Study of Parents and Children (ALSPAC) showed that at age 24, 1 in 5 had NAFLD measured by transient elastography and controlled attenuation parameter (CAP). Our aim was to investigate the association between breastfeeding duration and maternal pre-pregnancy BMI on offspring NAFLD in young adulthood.
methods4021 participants attended clinic for FibroScan and CAP measurement using Echosens 502 Touch®. 440 participants with Alcohol Use Disorders were excluded. Offspring of 100 non-singleton pregnancies were excluded. 2961 valid CAP measurements for NAFLD were analysed. Exposures of interest were breastfeeding of any duration, ≥6months exclusive breastfeeding, and maternal pre-pregnancy BMI. Multivariable regression models estimated the odds of NAFLD at 24 years. We performed a paternal negative control test to explore residual confounding in the analyses of pre-pregnancy BMI.
findingsThere was a modest inverse association of exclusive and non-exclusive breastfeeding ≥6 months having a protective effect on NAFLD in offspring (OR 0·92 [95%CI 0·66-1·27] and OR 0·90 [0·67-1·21] respectively).The odds of offspring NAFLD in overweight pre-pregnancy maternal BMI and paternal BMI was OR 2·09 [1·62-2·68] and OR 1·33 [95%CI 1·07-1·65] respectively, with the ratio of effect sizes OR 1·57 [1·11-2·22]. Similarly, odds of offspring NAFLD with obese pre-pregnancy maternal BMI and paternal BMI was OR 2·66 [1·71-4·14] and OR 1·35 [0·91-2·00] respectively, with the ratio of effect sizes OR 1·98 [1·05-3·74].
interpretationHigher maternal pre-pregnancy BMI was associated with offspring NAFLD, having accounted for shared parental confounding. We did not replicate previous work that found a strong association between breastfeeding and NAFLD.
fundingMedical Research Council UK, Alcohol Research UK, David Telling Charitable Trust.
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