Evidence map›Paper›PMID 34806058›Full record

ArticleGiant (Oxford, England)2021

Permeation of polyethylene glycols across the tympanic membrane.

Wei Zhang, Brendan Harty, Yueqin Zheng, Zipei Zhang, Xiyu Li, Dali Wang, Daniel S Kohane

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Giant (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wei ZhangLaboratory for Biomaterials and Drug Delivery, The Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Brendan HartyLaboratory for Biomaterials and Drug Delivery, The Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Yueqin ZhengLaboratory for Biomaterials and Drug Delivery, The Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Zipei ZhangLaboratory for Biomaterials and Drug Delivery, The Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Xiyu LiLaboratory for Biomaterials and Drug Delivery, The Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Dali WangLaboratory for Biomaterials and Drug Delivery, The Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Daniel S KohaneLaboratory for Biomaterials and Drug Delivery, The Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Boston Children's Hospital · US

Funding

Development of innovative therapeutics for otitis mediaR01DC015557 · NIDCD · GEORGIA STATE UNIVERSITY · PI KOHANE, DANIEL S, LI, JIAN-DONG · 2018 to 2022
$2.9M
Trans-tympanic delivery of antibioticsR01DC015050 · NIDCD · BOSTON CHILDREN'S HOSPITAL · PI KOHANE, DANIEL S · 2016 to 2020
$2.8M
NIDCD NIH HHS R01 DC015050NIDCD NIH HHS R01 DC015557
6 · The paper itself

Abstract

Localized and non-invasive delivery of therapeutics across barriers in the body is challenging. Examples include the flux of drugs across the tympanic membrane (TM) for the treatment of middle ear infections, and across the round window to treat inner ear disease. With the emergence of macromolecular therapies, the question arises as to whether such delivery can be achieved with macromolecules. Here, we have used polyethylene glycols (PEGs) in solutions to investigate macromolecular permeation across the TM in the chinchilla

Indexed as

Across barriersMolecular weightNoninvasive trans-tympanic deliveryPolyethylene glycol

Identifiers

PMID34806058
PMCPMC8601659
OpenAlexW3214277641

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.