Evidence map›Paper›PMID 34806017›Full record

ArticleBioinformatics advances2021

CRIS: complete reconstruction of immunoglobulin

Rashedul Islam, Misha Bilenky, Andrew P Weng, Joseph M Connors, Martin Hirst

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformatics advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Single-Cell Transcriptomic Analysis of Normal and Malignant B Cells.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rashedul IslamBioinformatics Graduate Program, University of British Columbia, Vancouver, BC V5Z 4S6, Canada.ORCID https://orcid.org/0000-0001-6747-6191
Misha BilenkyCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC V5Z 4S6, Canada.
Andrew P WengTerry Fox Laboratory, BC Cancer, Vancouver, BC V5Z 1L3, Canada.
Joseph M ConnorsDepartment of Medical Oncology, BC Cancer, Vancouver, BC, V5Z 4E6, Canada.ORCID https://orcid.org/0000-0002-1361-7531
Martin HirstBioinformatics Graduate Program, University of British Columbia, Vancouver, BC V5Z 4S6, Canada.
University of British Columbia · CACanada's Michael Smith Genome Sciences Centre · CA

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M
GM-CSF - producing tumor cell line as a CML vaccineR21CA115043 · NCI · DANA-FARBER CANCER INSTITUTE · PI WU, CATHERINE JU-YING · 2005 to 2006
$654k
NCI NIH HHS R21 CA115043NHGRI NIH HHS U54 HG003067
6 · The paper itself

Abstract

motivationB cells display remarkable diversity in producing B-cell receptors through recombination of immunoglobulin (Ig)

resultsCRIS extracts RNA-seq reads aligned to Ig gene loci, performs assembly of Ig transcripts and aligns the resulting contigs to reference Ig sequences to enumerate and classify SHMs in the AVAILABILITY AND IMPLEMENTATION: The CRIS pipeline is available under the MIT License from https://github.com/Rashedul/CRIS. SUPPLEMENTARY INFORMATION: Supplementary data are available at

Identifiers

PMID34806017
PMCPMC8600631
OpenAlexW3201257126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.