Evidence map›Paper›PMID 34805999›Full record

ArticleBrain communications2021

Tackling clinical heterogeneity across the amyotrophic lateral sclerosis-frontotemporal dementia spectrum using a transdiagnostic approach.

Rebekah M Ahmed, Martina Bocchetta, Emily G Todd, Nga Yan Tse, Emma M Devenney, Sicong Tu, Jashelle Caga, John R Hodges, Glenda M Halliday, Muireann Irish and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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  13. Frontotemporal lobar degeneration.Nature reviews. Disease primers · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Rebekah M AhmedMemory and Cognition Clinic, Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney 2050, Australia.ORCID https://orcid.org/0000-0001-6996-8317
Martina BocchettaDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1E, UK.ORCID https://orcid.org/0000-0003-1814-5024
Emily G ToddDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1E, UK.ORCID https://orcid.org/0000-0003-1551-5691
Nga Yan TseBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.ORCID https://orcid.org/0000-0002-1471-4835
Emma M DevenneyBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.
Sicong TuBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.
Jashelle CagaBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.
John R HodgesBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.
Glenda M HallidayBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.ORCID https://orcid.org/0000-0003-0422-8398
Muireann IrishSchool of Psychology and Brain and Mind Centre, The University of Sydney, Sydney 2050, Australia.ORCID https://orcid.org/0000-0002-4950-8169
Matthew C KiernanMemory and Cognition Clinic, Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney 2050, Australia.
Olivier PiguetSchool of Psychology and Brain and Mind Centre, The University of Sydney, Sydney 2050, Australia.
Jonathan D RohrerDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1E, UK.
The University of Sydney · AUUK Dementia Research Institute · GB

Funding

Medical Research Council MR/J009482/1Medical Research Council MR/M008525/1Medical Research Council MR/M023664/1Medical Research Council MR/T046015/1
6 · The paper itself

Abstract

The disease syndromes of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) display considerable clinical, genetic and pathological overlap, yet mounting evidence indicates substantial differences in progression and survival. To date, there has been limited examination of how profiles of brain atrophy might differ between clinical phenotypes. Here, we address this longstanding gap in the literature by assessing cortical and subcortical grey and white matter volumes on structural MRI in a large cohort of 209 participants. Cognitive and behavioural changes were assessed using the Addenbrooke's Cognitive Examination and the Cambridge Behavioural Inventory. Relative to 58 controls, behavioural variant FTD (

Indexed as

behaviouralcognitionFrontotemporal dementia-amyotrophic lateral sclerosisimaging

Identifiers

PMID34805999
PMCPMC8599039
OpenAlexW3208023205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.