Evidence map›Paper›PMID 34805821›Full record

ArticleMatrix biology plus2021

Runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification.

Harunur Rashid, Haiyan Chen, Amjad Javed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Matrix biology plus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Nf2 orchestrates β-arrestin2-biased PTH1R signaling to couple bone mass with skeletal integrity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. A RUNX2 reporter is expressed prior to osteochondral differentiation and models metaphyseal dysplasia with maxillary hypoplasia and brachydactyly.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Harunur RashidDepartment of Oral and Maxillofacial Surgery, Institute of Oral Health Research, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL, USA.
Haiyan ChenDepartment of Oral and Maxillofacial Surgery, Institute of Oral Health Research, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL, USA.
Amjad JavedDepartment of Oral and Maxillofacial Surgery, Institute of Oral Health Research, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · US

Funding

Dental Academic Research Training Program (DART)T90DE022736 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Amjad Javed · 2012 to 2026
$6.7M
Sp7 Mediated Control of Runx2 Function for Osteoblast DifferentiationR01AR062091 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAVED, AMJAD · 2012 to 2025
$3.4M
Osteoblasts Role in Dysfunction of Body Adiposity and Bone MetabolismR56AG065129 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAVED, AMJAD · 2020 to 2020
$393k
NIAMS NIH HHS R01 AR062091NIA NIH HHS R56 AG065129NIDCR NIH HHS T90 DE022736
6 · The paper itself

Abstract

The RUNX2 transcription factor is a key regulator for the development of cartilage and bone. Global or resting chondrocyte-specific deletion of the

Indexed as

ACAN, AggrecanAggrecanaseApoptosisBAC, Bacterial artificial chromosomeCCND1, Cyclin D1CDK1, Cyclin-dependent kinase 1Chondroclast/osteoclastCOL10, Collagen type XCOL2, Collagen type IIDwarfismIHH, Indian hedgehogMatrix-metalloproteinaseMMP, Matrix metalloproteinaseOPG, OsteoprotegerinPCNA, Proliferating cell nuclear antigenPTHRP, Parathyroid hormone-related peptideRANKL, Receptor activator of nuclear factor Kappa B ligandRUNX2, Runt related transcription factor 2SOX9, SRY box transcription factorTNAP, Tissue-nonspecific alkaline phosphataseTRAP, Tartrate-resistant acid phosphataseVEGFA, Vascular endothelial growth factor aWnt/PCP, Wnt/planar cell polarity

Identifiers

PMID34805821
PMCPMC8586806
OpenAlexW3209083126

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.