Evidence map›Paper›PMID 34805788›Full record

ArticleiScience2021

A model of impaired Langerhans cell maturation associated with HPV induced epithelial hyperplasia.

Zewen K Tuong, Samuel W Lukowski, Quan H Nguyen, Janin Chandra, Chenhao Zhou, Kevin Gillinder, Abate A Bashaw, John R Ferdinand, Benjamin J Stewart, Siok Min Teoh and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Targeted Cancer Immunotherapy: Nanoformulation Engineering and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Zewen K TuongThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
Samuel W LukowskiAustralia Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
Quan H NguyenAustralia Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
Janin ChandraThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
Chenhao ZhouThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
Kevin GillinderThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
Abate A BashawThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
John R FerdinandMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC-Laboratory of Molecular Biology, Cambridge, UK.
Benjamin J StewartMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC-Laboratory of Molecular Biology, Cambridge, UK.
Siok Min TeohThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
Sarah J HansonThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
Katharina DevittThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
Menna R ClatworthyMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC-Laboratory of Molecular Biology, Cambridge, UK.
Joseph E PowellGarvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Ian H FrazerThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
University of Queensland · AUUniversity of Cambridge · GBGarvan Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Langerhans cells (LC) are skin-resident antigen-presenting cells that regulate immune responses to epithelial microorganisms. Human papillomavirus (HPV) infection can promote malignant epithelial transformation. As LCs are considered important for controlling HPV infection, we compared the transcriptome of murine LCs from skin transformed by K14E7 oncoprotein and from healthy skin. We identified transcriptome heterogeneity at the single cell level amongst LCs in normal skin, associated with ontogeny, cell cycle, and maturation. We identified a balanced co-existence of immune-stimulatory and immune-inhibitory LC cell states in normal skin that was significantly disturbed in HPV16 E7-transformed skin. Hyperplastic skin was depleted of immune-stimulatory LCs and enriched for LCs with an immune-inhibitory gene signature, and LC-keratinocyte crosstalk was dysregulated. We identified reduced expression of interleukin (IL)-34, a critical molecule for LC homeostasis. Enrichment of an immune-inhibitory LC gene signature and reduced levels of epithelial IL-34 were also found in human HPV-associated cervical epithelial cancers.

Indexed as

BioinformaticsBiological sciencesImmune systemTranscriptomics

Identifiers

PMID34805788
PMCPMC8586807
OpenAlexW3205777156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.