ArticleInternational journal of reproductive biomedicine2021
Impacts of garlic extract on testicular oxidative stress and sperm characteristics in type 1 and 2 diabetic rats: An experimental study.
Article in International journal of reproductive biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Animal models for improving reproductive efficiency using medicinal plants: A review.Open veterinary journal · 2026Review
- Development and validation of a machine learning model for sperm DNA fragmentation rate in infertile men: a multicenter retrospective study.Frontiers in endocrinology · 2026Article
- Ameliorative effects of vitamin C and garlic (Frontiers in veterinary science · 2025Article
- Chemical analysis of Alliin-RichToxicology reports · 2024Article
- Effects of garlic (Allium sativum L) and Citrullus colocynthis (L.) Schrad individually and in combination on male reproductive damage due to diabetes: suppression of the AGEs/RAGE/Nox-4 signaling pathway.BMC complementary medicine and therapies · 2024Article
- Effect ofFrontiers in veterinary science · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyperglycemia damages various tissues such as the testes through oxidative stress and inflammation, which can eventually lead to infertility.
objectiveGarlic extract effects on the testicular tissue of diabetic rats were investigated. MATERIALS AND
methodsIn this experimental study, 36 male Wistar rats (8-wk old, weighing 230-300 gr) were randomly divided into 6 groups (n = 6/each) including; C: control rats, G: received 0.4 gr of garlic extract/100 gr body weight, D1: Streptozotocin-induced-diabetic rats or type 1, D1+G: D1 rats that were treated with garlic, D2: Streptozotocin + nicotinamide-induced-diabetic rats or type 2, D2+G: D2 rats treated with garlic. At the end of the study, serum testosterone was assayed by ELISA. Also, sperm quality and quantity were evaluated. For determination of oxidative stress status, total antioxidant capacity, total oxidative status, lipid peroxidation, and thiol groups were assayed in the testis tissues of the rats by colorimetric methods. Also, inducible nitric oxide synthase (
resultsIn diabetic rats, glucose, total oxidative status and lipid peroxidation,
conclusionIn diabetic rats, garlic was associated with reduced glucose, oxidative stress, IL-1
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