Evidence map›Paper›PMID 34805566›Full record

ArticleHeliyon2021

Landscape of Hopx expression in cells of the immune system.

Jessica Bourque, Adeleye Opejin, Alexey Surnov, Courtney A Iberg, Cindy Gross, Rajan Jain, Jonathan A Epstein, Daniel Hawiger

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jessica BourqueDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63118, USA.
Adeleye OpejinDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63118, USA.
Alexey SurnovDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63118, USA.
Courtney A IbergDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63118, USA.
Cindy GrossDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63118, USA.
Rajan JainDepartment of Medicine, Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jonathan A EpsteinDepartment of Medicine, Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Daniel HawigerDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63118, USA.
Saint Louis University · USUniversity of Pennsylvania · US

Funding

The Role of BRD4 in Cardiac SpecificationR01HL139783 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JAIN, RAJAN · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL139783
6 · The paper itself

Abstract

Homeodomain only protein (Hopx) is a regulator of cell differentiation and function, and it has also emerged as a crucial marker of specific developmental and differentiation potentials. Hopx expression and functions have been identified in some stem cells, tumors, and in certain immune cells. However, expression of Hopx in immune cells remains insufficiently characterized. Here we report a comprehensive pattern of Hopx expression in multiple types of immune cells under steady state conditions. By utilizing single-cell RNA sequencing (scRNA-seq) and flow cytometric analysis, we characterize a constitutive expression of Hopx in specific subsets of CD4

Indexed as

ExpressionFlow cytometryHopxImmune cellsMicescRNA-seqSteady state

Identifiers

PMID34805566
PMCPMC8590040
OpenAlexW3210508974

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.