ArticlePhysics and imaging in radiation oncology2021
Normal tissue complication probability models for prospectively scored late rectal and urinary morbidity after proton therapy of prostate cancer.
Article in Physics and imaging in radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- Independent validation of a dysphagia dose response model for the selection of head and neck cancer patients to proton therapy.Physics and imaging in radiation oncology · 2022Article
- Achievements and challenges in normal tissue response modelling for proton therapy.Physics and imaging in radiation oncology · 2022Article
- Predictive modelling for late rectal and urinary toxicities after prostate radiotherapy using planned and delivered dose.Frontiers in oncology · 2022Article
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Authors and funding
6 authors.
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Abstract
background and purposePhotons and protons have fundamentally different properties, i.e. protons have a reduced dose bath but a higher relative biological effectiveness. Photon-based normal tissue complication probability (NTCP) models may therefore not immediately be applicable to proton therapy (PT). The aim was to derive parameters of the Lyman-Kutcher-Burman (LKB) NTCP model using prospectively recorded late morbidity data from PT, focusing on rectal morbidity and prostate cancer. MATERIALS AND
methodsProspectively collected data were available for 1151 prostate cancer patients treated with passive scattering PT and prescribed target doses of 78-82 Gy (RBE = 1.1) in 2 Gy fractions. Morbidity data (CTCAE v3.0) consisted of two alternative late grade 2 rectal bleeding endpoints: Medical Grade2A (GR2A) and procedural Grade2B (GR2B), as well as late grade 3 + urinary morbidity. GR2A + 2B were observed in 156/1047 patients (15%), GR2B in 45/1047 patients (4%), and urinary grade 3 + in 51/1151 patients (4%). LKB NTCP model parameters (D50,
resultsFor the rectum/rectal wall the volume parameter
conclusionPT specific LKB NTCP model parameters were derived from a population of more than 1000 patients. The D50 parameter differed for all structures and endpoints and deviated from typical photon-based LKB model values.
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