Evidence map›Paper›PMID 34805494›Full record

ArticleTransplantation direct2021

SARS-CoV-2-specific Humoral and Cellular Immunities in Kidney Transplant Recipients and Dialyzed Patients Recovered From Severe and Nonsevere COVID-19.

Dominique Bertrand, Mouad Hamzaoui, Laurent Drouot, Julie Lamulle, Mélanie Hanoy, Stéphane Edet, Charlotte Laurent, Ludivine Lebourg, Isabelle Etienne, Mathilde Lemoine and 6 more

Open access · goldAbstract read
In one paragraph

Article in Transplantation direct, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Dominique BertrandDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Mouad HamzaouiDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Laurent DrouotNormandy University, UNIROUEN, INSERM U1234, Rouen, France.
Julie LamulleNormandy University, UNIROUEN, INSERM U1234, Rouen, France.
Mélanie HanoyDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Stéphane EdetDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Charlotte LaurentDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Ludivine LebourgDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Isabelle EtienneDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Mathilde LemoineDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Frank Le RoyDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Dorian NezamDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Eleusis MaugerDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Olivier BoyerNormandy University, UNIROUEN, INSERM U1234, Rouen, France.
Dominique GuerrotDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Sophie CandonNormandy University, UNIROUEN, INSERM U1234, Rouen, France.
Université de Rouen Normandie · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney transplantation and dialysis are two major risk factors for severe forms of coronavirus disease 2019 (COVID-19). The dynamics of the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in this population remain largely unknown.

methodsWe report here the analysis of anti-SARS-CoV-2 antibody- and T cell-mediated immune responses in 26 kidney transplant recipients (KTRs) and 11 dialyzed patients (DPs) who recovered from COVID-19.

resultsAfter a mean time of 83 ± 26 d post-symptom onset for KTRs and 97 ± 31 d for DPs, 20 KTRs (76.9%) and 10 DPs (90.9%) displayed anti-S1 immunoglobulin G SARS-CoV-2 antibodies (

conclusionT-cell response persisted up to 3 mo post-symptom onset, even in KTRs in whom full immunosuppressive regimen was reinstated at recovery, and seems to be present up to 10 mo after infection. Our findings have implications in the understanding of the natural course of the disease in transplant patients and DPs.

Identifiers

PMID34805494
PMCPMC8601300
OpenAlexW3215858752

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.