Evidence map›Paper›PMID 34805429›Full record

ReviewOpen forum infectious diseases2021

Harnessing the Potential of Multiomics Studies for Precision Medicine in Infectious Disease.

Rebecca A Ward, Nima Aghaeepour, Roby P Bhattacharyya, Clary B Clish, Brice Gaudillière, Nir Hacohen, Michael K Mansour, Philip A Mudd, Shravani Pasupneti, Rachel M Presti and 8 more

Open access · goldAbstract readReview
In one paragraph

Review in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  4. Review
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  6. Observational
  7. Article
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  9. Article
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  11. Article
  12. Review
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  14. Article
  15. [Precision medicine in infectious diseases].Innere Medizin (Heidelberg, Germany) · 2024
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 1 country.

Rebecca A WardDivision of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-6752-5600
Nima AghaeepourDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Roby P BhattacharyyaDivision of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Clary B ClishBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.ORCID https://orcid.org/0000-0001-8259-9245
Brice GaudillièreDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.ORCID https://orcid.org/0000-0002-3475-5706
Nir HacohenBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Michael K MansourDivision of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Philip A MuddDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-3860-5473
Shravani PasupnetiDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.ORCID https://orcid.org/0000-0002-7112-601X
Rachel M PrestiDivision of Infectious Diseases, Department of lnternal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-5469-0727
Eugene P RheeThe Nephrology Division and Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Pritha SenDivision of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Andrej SpecDivision of Infectious Diseases, Department of lnternal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0001-7612-4710
Jenny M TamHarvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-3767-7205
Alexandra-Chloé VillaniBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.ORCID https://orcid.org/0000-0001-7461-0408
Ann E WoolleyDivision of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Joe L HsuDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Jatin M VyasDivision of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9985-9565
Broad Institute · USHarvard University · USWashington University in St. Louis · USStanford University · USVA Palo Alto Health Care System · USBrigham and Women's Hospital · USMassachusetts General Hospital · US

Funding

UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community EngagementP01HD106414 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GIUDICE, LINDA C · 2021 to 2025
$7.1M
Control of Type I Interferon Production in Response to Candida albicansR01AI150181 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Jatin M Vyas · 2020 to 2026
$5.4M
A critical role for macrophage ferroptosis in promoting fungal invasion in lung transplant recipientsR01HL157414 · NHLBI · STANFORD UNIVERSITY · PI HSU, JOE L · 2021 to 2025
$3.0M
The Functional Role of the Tetraspanin CD82/Kai1 in Fungal Innate ImmunityR01AI136529 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2018 to 2022
$2.7M
Machine Learning for Integrative Modeling of the Immune System in Clinical SettingsR35GM138353 · NIGMS · STANFORD UNIVERSITY · PI AGHAEEPOUR, NIMA · 2020 to 2024
$2.2M
Harnessing the human monocyte system to improve surgical recoveryR35GM137936 · NIGMS · STANFORD UNIVERSITY · PI GAUDILLIERE, BRICE · 2020 to 2024
$2.0M
The role of spleen tyrosine kinase (syk) in neutrophil responses to pathogenic fungi.R01AI132638 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MANSOUR, MICHAEL K · 2018 to 2021
$1.6M
HIF-1 mediated vascular integrity limits Aspergillus invasion in airway rejectionK08HL122528 · NHLBI · STANFORD UNIVERSITY · PI HSU, JOE L · 2015 to 2019
$804k
NHLBI NIH HHS K08 HL122528NHLBI NIH HHS R01 HL157414NIAID NIH HHS R01 AI132638NIAID NIH HHS R01 AI136529NIAID NIH HHS R01 AI150181NICHD NIH HHS P01 HD106414NIGMS NIH HHS R35 GM137936NIGMS NIH HHS R35 GM138353
6 · The paper itself

Abstract

The field of infectious diseases currently takes a reactive approach and treats infections as they present in patients. Although certain populations are known to be at greater risk of developing infection (eg, immunocompromised), we lack a systems approach to define the true risk of future infection for a patient. Guided by impressive gains in "omics" technologies, future strategies to infectious diseases should take a precision approach to infection through identification of patients at intermediate and high-risk of infection and deploy targeted preventative measures (ie, prophylaxis). The advances of high-throughput immune profiling by multiomics approaches (ie, transcriptomics, epigenomics, metabolomics, proteomics) hold the promise to identify patients at increased risk of infection and enable risk-stratifying approaches to be applied in the clinic. Integration of patient-specific data using machine learning improves the effectiveness of prediction, providing the necessary technologies needed to propel the field of infectious diseases medicine into the era of personalized medicine.

Indexed as

high-throughput technologiesinfectious diseasesinvasive fungal infectionssystems immunology

Identifiers

PMID34805429
PMCPMC8598922
OpenAlexW3201705112

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.