Evidence map›Paper›PMID 34805406›Full record

ArticleBioMed research international2021

Predictors of Loss to Follow-Up among HIV-Infected Adults after Initiation of the First-Line Antiretroviral Therapy at Arba Minch General Hospital, Southern Ethiopia: A 5-Year Retrospective Cohort Study.

Mathewos Alemu Gebremichael, Mekdes Kondale Gurara, Haymanot Nigussie Weldehawaryat, Melkamu Merid Mengesha, Dessalegn Ajema Berbada

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mathewos Alemu GebremichaelSchool of Public Health, College of Medicine and Health Sciences, Arba Minch University, P.O. Box: 021, Arba Minch, Ethiopia.ORCID https://orcid.org/0000-0003-3652-9013
Mekdes Kondale GuraraSchool of Public Health, College of Medicine and Health Sciences, Arba Minch University, P.O. Box: 021, Arba Minch, Ethiopia.
Haymanot Nigussie WeldehawaryatSchool of Public Health, College of Medicine and Health Sciences, Arba Minch University, P.O. Box: 021, Arba Minch, Ethiopia.
Melkamu Merid MengeshaSchool of Public Health, College of Medicine and Health Sciences, Arba Minch University, P.O. Box: 021, Arba Minch, Ethiopia.ORCID https://orcid.org/0000-0003-4312-0136
Dessalegn Ajema BerbadaSchool of Public Health, College of Medicine and Health Sciences, Arba Minch University, P.O. Box: 021, Arba Minch, Ethiopia.
Arba Minch University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLoss to follow-up (LTFU) from antiretroviral therapy (ART) reduces treatment benefits and leads to treatment failure. Hence, this study was aimed at determining the incidence of loss to follow-up and predictors among HIV-infected adults who began first-line antiretroviral therapy at Arba Minch General Hospital.

methodsWe carried out an institutional-based retrospective cohort study, and data were collected from the charts of 508 patients who were selected using a simple random sampling technique. All the data management and statistical analyses were conducted using STATA version 14. Cumulative survival probability was estimated and presented in the life table, and the Kaplan-Meir survival curves were compared using the log-rank test. The Cox proportional hazard model was used to identify the independent predictors.

resultsWe followed 508 patients for 871.9 person-years. A total of 46 (9.1%) experienced loss to follow-up, yielding an overall incidence rate of 5.3 (95% CI: 3.9-7.1) per 100 person-years. The cumulative survival probability was 90%, 88%, 86%, and 86% at the end of one, two, three, and four years, respectively. The predictors identified were age less than 35 years (adjusted hazard ratio (aHR = 1.96; 95% CI: 1.92-4.00)), rural residence (aHR = 1.98; 95% CI: 1.02-3.83), baseline body weight greater than 60 kilograms (aHR = 2.19; 95% CI: 1.11-4.37), a fair level of adherence (aHR = 11.5; 95% CI: 2.10-61.10), and a poor level of adherence (aHR = 12.03; 95% CI: 5.4-26.7).

conclusionsIn this study, the incidence rate of loss to follow-up was low. Younger adults below the age of 35 years, living in rural areas, with a baseline weight greater than 60 kilograms, which had a fair and poor adherence level were more likely to be lost from treatment. Therefore, health professionals working in ART clinics and potential stakeholders in HIV/AIDS care and treatment should consider adult patients with these characteristics to prevent LTFU.

Indexed as

Lost to Follow-UpAdolescentAdultAnti-HIV AgentsCohort StudiesEthiopiaFemaleFollow-Up StudiesHIV InfectionsHospitals, GeneralHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedProportional Hazards ModelsAnti-HIV Agents

Identifiers

PMID34805406
PMCPMC8601861
OpenAlexW3213695213

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.