Evidence map›Paper›PMID 34805404›Full record

ArticleBioMed research international2021

KIF4A Regulates the Progression of Pancreatic Ductal Adenocarcinoma through Proliferation and Invasion.

Jing Chen, Cui-Cui Zhao, Fei-Ran Chen, Guo-Wei Feng, Fei Luo, Tao Jiang

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jing ChenCollege of Life Science, Nankai University, No. 94 Weijin Road, Nankai District, Tianjin 300071, China.
Cui-Cui ZhaoDepartment of VIP Ward, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Huanhuxi Road, Hexi District, Tianjin 300060, China.
Fei-Ran ChenDepartment of Genitourinary Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, No. 24, Binshui Street, Hexi District, Tianjin 300060, China.
Guo-Wei FengDepartment of Genitourinary Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, No. 24, Binshui Street, Hexi District, Tianjin 300060, China.
Fei LuoDepartment of Urology, Tianjin People's Hospital, No. 190, Jieyuan Road, Hongqiao District, Tianjin 300121, China.
Tao JiangDepartment of General Surgery, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyuncang, Dongcheng District, 100700 Beijing, China.ORCID https://orcid.org/0000-0002-8832-9251
Tianjin Medical University Cancer Institute and Hospital · CNBeijing University of Chinese Medicine · CNNankai University · CNTianjin People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPancreatic cancer is a malignant tumor of the digestive tract, which is difficult to diagnose and treat due to bad early diagnosis. We aimed to explore the role of kinesin superfamily 4A (KIF4A) in pancreatic ductal adenocarcinoma (PDAC).

methodsWe first used the bioinformatic website to screen the data of pancreatic cancer in TCGA, and KIF4A protein was detected among the 86 specimens of patients in our hospital combined with clinic-pathological characteristics and survival analysis. KIF4A loss-expression cell lines were established by RNA interference (RNAi). In addition, we performed in vitro cell assays to detect the changes in cell proliferation, migration, and invasion. The proteins involved in the proliferation and metastasis of cancer cells were also detected by western blot. The above results could be proved in vivo. Further, the correlation between KIF4A and CDC5L was analyzed by TCGA and IHC data.

resultsWe first found a high expression of KIF4A in pancreatic cancer, suggesting a role of KIF4A in the development of pancreatic cancer. KIF4A was found to be differentially expressed (

conclusionIn conclusion, the high expression level of KIF4A in PDAC was closely related to poor clinical and pathological status, lymphatic metastasis, and vascular invasion. KIF4A might be involved in promoting the development of PDAC in vitro and in vivo, which might be a new therapeutic target of PDAC.

Indexed as

AnimalsBiomarkers, TumorCarcinoma, Pancreatic DuctalCell Cycle ProteinsCell Line, TumorCell ProliferationComputational BiologyDisease ProgressionFemaleGene Knockdown TechniquesHeterograftsHumansKinesinsMiceMice, Inbred BALB CMice, NudeBiomarkers, TumorCDC5L protein, humanCell Cycle ProteinsKIF4A protein, humanKinesinsRNA-Binding ProteinsRNA, Messenger

Identifiers

PMID34805404
PMCPMC8601854
OpenAlexW3213359803

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.