Evidence map›Paper›PMID 34805318›Full record

SynthesisFrontiers in cardiovascular medicine2021

Research Progress of Electrical Stimulation in Ischemic Heart Disease.

Ying Zhao, Pengyu Wang, Zhe Chen, Manman Li, Dengfeng Zhang, Liming Yang, Hong Li

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Complementary biomolecular coassemblies direct energy transport for cardiac photostimulators.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ying ZhaoDepartment of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Pengyu WangDepartment of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Zhe ChenDepartment of Infectious Diseases, Beidahuang Group General Hospital, Harbin, China.
Manman LiDepartment of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Dengfeng ZhangDepartment of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Liming YangDepartment of Pathophysiology, Harbin Medical University-Daqing, Daqing, China.
Hong LiDepartment of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic heart disease (IHD) is a considerable health burden worldwide with high mortality and morbidity. Treatments for IHD are mainly focused on decreasing oxygen demand or increasing myocardial oxygen supply, including pharmacological, interventional, and surgical treatment, but there are also some limitations. Therefore, it is important to find a simple, effective, and economical treatment. As non-invasive and safe physiotherapy, electrical stimulation (ES) has a promising application in the treatment of IHD. Current studies suggest that ES can affect the occurrence and development of IHD by promoting angiogenesis, regulating autophagy and apoptosis, inhibiting the inflammatory response and oxidative stress. In this review, we focus predominantly on the mechanism of ES and the current progress of ES therapy in IHD, furthermore, give a brief introduction to the forms of ES in clinical application.

Indexed as

angiogenesisapoptosisautophagyelectrical stimulationinflammationischemic heart diseaseoxidative stress

Identifiers

PMID34805318
PMCPMC8595213
OpenAlexW3210950593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.