Evidence map›Paper›PMID 34805145›Full record

ArticleFrontiers in cell and developmental biology2021

A Comparative Proteomic Analysis of Extracellular Vesicles Associated With Lipotoxicity.

Yasuhiko Nakao, Masanori Fukushima, Amy S Mauer, Chieh-Yu Liao, Anya Ferris, Debanjali Dasgupta, Carrie Jo Heppelmann, Patrick M Vanderboom, Mayank Saraswat, Akhilesh Pandey and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  4. Enolase and 16.5-kDa Tegument-Associated Protein inJournal of extracellular biology · 2025
    Article
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  16. TMAO-Activated Hepatocyte-Derived Exosomes Impair AngiogenesisFrontiers in cell and developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Yasuhiko NakaoDivision of Gastroenterology and Hepatology, Rochester, MN, United States.
Masanori FukushimaDivision of Gastroenterology and Hepatology, Rochester, MN, United States.
Amy S MauerDivision of Gastroenterology and Hepatology, Rochester, MN, United States.
Chieh-Yu LiaoDivision of Gastroenterology and Hepatology, Rochester, MN, United States.
Anya FerrisDivision of Gastroenterology and Hepatology, Rochester, MN, United States.
Debanjali DasguptaDivision of Gastroenterology and Hepatology, Rochester, MN, United States.
Carrie Jo HeppelmannMayo Clinic Medical Genome Facility-Proteomics Core, Manipal, India.
Patrick M VanderboomMayo Clinic Medical Genome Facility-Proteomics Core, Manipal, India.
Mayank SaraswatDepartment of Laboratory Medicine and Pathology, Rochester, MN, United States.
Akhilesh PandeyDepartment of Laboratory Medicine and Pathology, Rochester, MN, United States.
K Sreekumaran NairMayo Endocrine Research Unit, Manipal, India.
Alina M AllenDivision of Gastroenterology and Hepatology, Rochester, MN, United States.
Kazuhiko NakaoDepartment of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Harmeet MalhiDivision of Gastroenterology and Hepatology, Rochester, MN, United States.
University of Minnesota Rochester · USManipal Academy of Higher Education · INNagasaki University · JP

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI Nicholas F. LaRusso · 2009 to 2026
$22.2M
Pathobiology of Liver InjuryR01DK111378 · NIDDK · MAYO CLINIC ROCHESTER · PI MALHI, HARMEET · 2016 to 2025
$3.9M
NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK111378
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are emerging mediators of intercellular communication in nonalcoholic steatohepatitis (NASH). Palmitate, a lipotoxic saturated fatty acid, activates hepatocellular endoplasmic reticulum stress, which has been demonstrated to be important in NASH pathogenesis, including in the release of EVs. We have previously demonstrated that the release of palmitate-stimulated EVs is dependent on the

Indexed as

DAMPexosomehepatocytemicrovesicleStAR-related lipid transfer domain 11

Identifiers

PMID34805145
PMCPMC8600144
OpenAlexW3211714278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.