Evidence map›Paper›PMID 34805136›Full record

ArticleFrontiers in cell and developmental biology2021

T Cell Immunity Evaluation and Immunodominant Epitope T Cell Receptor Identification of Severe Acute Respiratory Syndrome Coronavirus 2 Spike Glycoprotein in COVID-19 Convalescent Patients.

Luo Li, Qian Chen, Xiaojian Han, Meiying Shen, Chao Hu, Siyin Chen, Jing Zhang, Yingming Wang, Tingting Li, Jingjing Huang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Luo LiDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Qian ChenDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Xiaojian HanDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Meiying ShenDepartment of Endocrine Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chao HuDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Siyin ChenDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Jing ZhangDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Yingming WangDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Tingting LiDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Jingjing HuangDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Shenglong LiDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Yanan HaoDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Aishun JinDepartment of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Chongqing Medical University · CNFirst Affiliated Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A better understanding of the role of T cells in the immune response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is helpful not only for vaccine development but also for the treatment of COVID-19 patients. In this study, we determined the existence of SARS-CoV-2-specific T cells in the blood of COVID-19 convalescents. Meanwhile, the specific T cell response in the non-RBD region was stronger than in the RBD region. We also found that SARS-CoV-2 S-specific reactive CD4

Indexed as

COVID-19SARS-CoV-2T cell epitopeTCRTCR-T

Identifiers

PMID34805136
PMCPMC8595245
OpenAlexW3209940642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.