Evidence map›Paper›PMID 34804941›Full record

ArticleFrontiers in oncology2021

Mitotic Errors Promote Genomic Instability and Leukemia in a Novel Mouse Model of Fanconi Anemia.

Donna M Edwards, Dana K Mitchell, Zahi Abdul-Sater, Ka-Kui Chan, Zejin Sun, Aditya Sheth, Ying He, Li Jiang, Jin Yuan, Richa Sharma and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Donna M EdwardsDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.
Dana K MitchellDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.
Zahi Abdul-SaterDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, United States.
Ka-Kui ChanDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.
Zejin SunWells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, United States.
Aditya ShethDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.
Ying HeWells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, United States.
Li JiangWells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, United States.
Jin YuanWells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, United States.
Richa SharmaWells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, United States.
Magdalena CzaderDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.
Pei-Ju ChinLaboratory of Molecular Gerontology, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Yie LiuLaboratory of Molecular Gerontology, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Guillermo de CárcerCancer Biology Department, Instituto de Investigaciones Biomédicas "Alberto Sols" (IIBM), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Grzegorz NalepaDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.
Hal E BroxmeyerLaboratory of Molecular Gerontology, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
D Wade ClappDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.
Elizabeth A Sierra PotchanantDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, Indiana University School of Medicine, Indianapolis, IN, United States.
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · USNational Institutes of Health · USInstituto de Investigaciones Biomédicas Sols-Morreale · ESRiley Hospital for Children · US

Funding

Mitotic failure in Fanconi anemia: mechanisms and role in carcinogenesisR01HL132921 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI CLAPP, DAVID W · 2017 to 2020
$1.8M
NHLBI NIH HHS R01 HL132921
6 · The paper itself

Abstract

Fanconi anemia (FA) is a disease of genomic instability and cancer. In addition to DNA damage repair, FA pathway proteins are now known to be critical for maintaining faithful chromosome segregation during mitosis. While impaired DNA damage repair has been studied extensively in FA-associated carcinogenesis

Indexed as

FANCCFanconi anemiagenomic instabilityleukemiaspindle assembly checkpoint

Identifiers

PMID34804941
PMCPMC8602820
OpenAlexW3214654448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.