Evidence map›Paper›PMID 34804862›Full record

ArticleInternational journal of ophthalmology2021

Individuals with and without normal tension glaucoma exhibit comparable performance on tests of cognitive function.

Qi N Cui, David Green, Mohit Jethi, Todd Driver, Travis C Porco, Jane Kuo, Shan C Lin, Robert L Stamper, Ying Han, Cynthia S Chiu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Qi N CuiDepartment of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.
David GreenDepartment of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.
Mohit JethiDepartment of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.
Todd DriverDepartment of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.
Travis C PorcoDepartment of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.
Jane KuoDepartment of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.
Shan C LinDepartment of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.
Robert L StamperDepartment of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.
Ying HanDepartment of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.
Cynthia S ChiuDepartment of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.
Saras RamanathanDepartment of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.
Michael E WardDepartment of Neurology, University of California San Francisco, San Francisco, California 94143, USA.
Katherine PossinDepartment of Neurology, University of California San Francisco, San Francisco, California 94143, USA.
Yvonne OuDepartment of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.
University of California, San Francisco · USNational Institutes of Health · US

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8M
NEI NIH HHS P30 EY002162
6 · The paper itself

Abstract

aimTo evaluate aspects of cognition impacted by individuals with and without normal tension glaucoma.

methodsFifty normal tension glaucoma (NTG) and 50 control patients ≥50y of age were recruited from the UCSF Department of Ophthalmology. Demographic data and glaucoma parameters were extracted from electronic medical records for both groups. Tests of executive function [Executive Abilities: Measures and Instruments for Neurobehavioral Evaluation and Research (EXAMINER)] and learning and memory [California Verbal Learning Test-Second Edition (CVLT-II)] were administered to both NTG and controls. Race, handedness, best-corrected visual acuity, maximum intraocular pressure, optic nerve cup-to-disc ratio, visual field and optic nerve optical coherence tomography parameters, and a measure of general health (Charlson Comorbidity Index) were compared between NTG and controls as well as within NTG subgroups. Multivariate linear regression was used to compare group performances on the EXAMINER battery and CVLT-II while controlling for age, sex, and years of education.

resultsNTG and controls were comparable with respect to age, sex, race, education, handedness, and the Charlson Comorbidity Index (

conclusionThis is the first prospective study in which the cognitive function of subject with NTG were evaluated using a comprehensive, computerized neurocognitive battery. Subjects with NTG do not perform worse than unaffected controls on tests of executive function, learning, and memory. Results do not support the hypothesis that individuals with NTG are at higher risk for cognitive dysfunction and/or dementia.

Indexed as

dementialow tension glaucomamemory and executive functionmild cognitive impairmentneurodegeneration

Identifiers

PMID34804862
PMCPMC8569564
OpenAlexW3210160177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.