ArticlePhotoacoustics2022
Ultraviolet photoacoustic microscopy with tissue clearing for high-contrast histological imaging.
Article in Photoacoustics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Ultraviolet Sensing-Guided Biomedical Systems: From Label-Free Imaging to Dosimetry and Therapy Feedback.Biosensors · 2026Review
- Revealing hidden tissue architecture with mid-infrared dichroism photoacoustic microscopy.Light, science & applications · 2026Article
- Current progress of labeling strategies in tissue clearing for large-scale biological visualization.Frontiers in cell and developmental biology · 2026Review
- A comprehensive review of high-performance photoacoustic microscopy systems.Photoacoustics · 2025Review
- Recent advancements in molecular photoacoustic tomography.JPhys photonics · 2025Review
- Quantifying UV-induced photodamage for longitudinal live-cell imaging applications of deep-UV microscopy.Biomedical optics express · 2025Article
- Review of low-cost light sources and miniaturized designs in photoacoustic microscopy.Journal of biomedical optics · 2024Review
- Dual-wavelength UV-visible metalens for multispectral photoacoustic microscopy: A simulation study.Photoacoustics · 2023Article
- Functional photoacoustic microscopy of hemodynamics: a review.Biomedical engineering letters · 2022Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultraviolet photoacoustic microscopy (UV-PAM) has been investigated to provide label-free and registration-free volumetric histological images for whole organs, offering new insights into complex biological organs. However, because of the high UV absorption of lipids and pigments in tissue, UV-PAM suffers from low image contrast and shallow image depth, hindering its capability for revealing various microstructures in organs. To improve the UV-PAM imaging contrast and imaging depth, here we propose to implement a state-of-the-art optical clearing technique, CUBIC (clear, unobstructed brain/body imaging cocktails and computational analysis), to wash out the lipids and pigments from tissues. Our results show that the UV-PAM imaging contrast and quality can be significantly improved after tissue clearing. With the cleared tissue, multilayers of cell nuclei can also be extracted from time-resolved PA signals. Tissue clearing-enhanced UV-PAM can provide fine details for organ imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.