Evidence map›Paper›PMID 34804281›Full record

ArticleWorld journal of oncology2021

Metastatic Clear Cell Renal Cell Carcinoma: The Great Pretender and the Great Dilemma.

Umberto Maestroni, Donatello Gasparro, Francesco Ziglioli, Giulio Guarino, Davide Campobasso

Open access · diamondAbstract readCase Reports
In one paragraph

Article in World journal of oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Umberto MaestroniDepartment of Urology, University Hospital of Parma/Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, Parma 43126, Italy.
Donatello GasparroMedical Oncology Unit, University Hospital of Parma/Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, Parma 43126, Italy.
Francesco ZiglioliDepartment of Urology, University Hospital of Parma/Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, Parma 43126, Italy.
Giulio GuarinoDepartment of Urology, University Hospital of Parma/Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, Parma 43126, Italy.
Davide CampobassoDepartment of Urology, University Hospital of Parma/Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, Parma 43126, Italy.ORCID https://orcid.org/0000-0003-2072-114X
Ospedale di Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastatic renal cell carcinoma (mRCC) may present with a wide range of clinical pictures. Reportedly, paraneoplastic syndromes are the first sign in 20% of cases and only 15% of cases show the classic triad (flank pain, gross hematuria, and palpable abdominal mass) at presentation. The remaining cases present with signs and symptoms related to the site of distant metastases. These data may explain the reason why about 20-30% of patients are metastatic at presentation. We report the case of a 63-year-old woman who came to our attention for lower back pain. After imaging studies, we detected a left kidney mass of 86 × 61 × 79 mm, multiple right pulmonary nodules and six bone lesions. She underwent left radical nephrectomy. After 1 month, she developed signs of spinal cord compression with neurological deficits and she underwent emergency spinal decompression. In order to allow complete motor recovery, the subsequent stereotactic body radiation therapy was not performed, and she is currently taking combination immunotherapy regimens. Management of mRCC is in a continuous evolution due to availability of new target therapies and the possibility of a multimodal approach with surgical, focal and radiotherapy treatments. However, the ideal treatment algorithm is yet to come. This is why mRCC diagnosis and management are still challenging for the clinicians.

Indexed as

Cytoreductive nephrectomyDiagnosisImmunotherapy-based combination therapyMetastatic renal cell carcinomaMultidisciplinary management

Identifiers

PMID34804281
PMCPMC8577602
OpenAlexW3211158218

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.