ArticleBehavioural neurology2021
Upper and Lower Limb Motor Function Correlates with Ipsilesional Corticospinal Tract and Red Nucleus Structural Integrity in Chronic Stroke: A Cross-Sectional, ROI-Based MRI Study.
Article in Behavioural neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Longitudinal automated fiber quantification reveals corticospinal tract dynamics and prognostic significance after primary basal ganglia hemorrhage.Neuroradiology · 2026Article
- Neurophysiological Predictors of Proximal Motor Rehabilitation in Stroke Patients with Corticospinal Tract Damage.Brain sciences · 2026Article
- The relationship between corticospinal tract and the affected lower limb function and walking ability in subacute stroke patients: a preliminary study.Journal of physical therapy science · 2026Article
- Observational
- Somatosensory-Thalamic Functional Dysconnectivity Associated With Poststroke Motor Function Rehabilitation: A Resting-State fMRI Study.Brain and behavior · 2025Article
- The impact of brain network microstructural changes on upper limb mirror movements after stroke.Frontiers in neurology · 2025Article
- Constraint-Induced Movement Therapy Promotes Contralesional Red Nucleus Plasticity and Increases Bilateral Motor Cortex-to-Red Nucleus Projections After a Large-Area Stroke.Behavioural neurology · 2025Article
- Assessing the cortical microstructure in contralesional sensorimotor areas after stroke.Brain communications · 2024Article
- Systematic Evaluation of the Effects of Voluntary Activation on Lower Extremity Motor Thresholds.Journal of clinical medicine · 2023Article
- Associating Functional Neural Connectivity and Specific Aspects of Sensorimotor Control in Chronic Stroke.Sensors (Basel, Switzerland) · 2023Article
- Long-Term Lower Limb Motor Function Correlates with Middle Cerebellar Peduncle Structural Integrity in Sub-Acute Stroke: A ROI-Based MRI Cohort Study.Brain sciences · 2023Article
- Variation in the rate of recovery in motor function between the upper and lower limbs in patients with stroke: some proposed hypotheses and their implications for research and practice.Frontiers in neurology · 2023Article
- The role of corticospinal and extrapyramidal pathways in motor impairment after stroke.Brain communications · 2023Article
- Association between superior longitudinal fasciculus, motor recovery, and motor outcome after stroke: a cohort study.Frontiers in neurology · 2023Article
- DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke.Frontiers in neuroscience · 2023Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundStructural integrity of the ipsilesional corticospinal tract (CST) is important for upper limb motor recovery after stroke. However, additional neuromechanisms associated with motor function poststroke are less well understood, especially regarding the lower limb.
objectiveTo investigate the neural basis of upper/lower limb motor deficits poststroke by correlating measures of motor function with diffusion tensor imaging-derived indices of white matter integrity (fractional anisotropy (FA), mean diffusivity (MD)) in primary and secondary motor tracts/structures.
methodsForty-three individuals with chronic stroke (time poststroke, 64.4 ± 58.8 months) underwent a comprehensive motor assessment and MRI scanning. Correlation and multiple regression analyses were performed to examine relationships between FA/MD in a priori motor tracts/structures and motor function.
resultsFA in the ipsilesional CST and red nucleus (RN) was positively correlated with motor function of both the affected upper and lower limb (
conclusionsMicrostructural integrity of the ipsilesional CST is associated with both upper and lower limb motor function poststroke, but appears less important for gait speed. Integrity of the ipsilesional RN was also associated with motor performance, suggesting increased contributions from secondary motor areas may play a role in supporting chronic motor function and could become a target for interventions.
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