Evidence map›Paper›PMID 34804035›Full record

ArticleFrontiers in immunology2021

Generation of an NFκB-Driven Alpharetroviral "All-in-One" Vector Construct as a Potent Tool for CAR NK Cell Therapy.

Loreen Sophie Rudek, Katharina Zimmermann, Melanie Galla, Johann Meyer, Johannes Kuehle, Andriana Stamopoulou, Daniel Brand, I Erol Sandalcioglu, Belal Neyazi, Thomas Moritz and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 17 citations in OpenAlex.

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  3. Engineered CD4 T cells for in vivo delivery of therapeutic proteins.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Loreen Sophie RudekInstitute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Katharina ZimmermannInstitute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Melanie GallaInstitute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Johann MeyerInstitute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Johannes KuehleCenter for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Andriana StamopoulouInstitute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Daniel BrandInstitute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
I Erol SandalciogluDepartment of Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany.
Belal NeyaziDepartment of Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany.
Thomas MoritzInstitute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Claudia RossigDepartment of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.
Bianca AltvaterDepartment of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.
Christine S FalkInstitute of Transplant Immunology, Integrated Research and Treatment Center Transplantation, Hannover Medical School, Hannover, Germany.
Hinrich AbkenRegensburg Centre for Interventional Immunology, Department of Genetic Immunotherapy, University Hospital Regensburg, Regensburg, Germany.
Michael Alexander MorganInstitute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Axel SchambachInstitute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Medizinische Hochschule Hannover · DEOtto-von-Guericke University Magdeburg · DEUniversity Hospital Münster · DEUniversity Hospital Regensburg · DEUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune cell therapeutics are increasingly applied in oncology. Especially chimeric antigen receptor (CAR) T cells are successfully used to treat several B cell malignancies. Efforts to engineer CAR T cells for improved activity against solid tumors include co-delivery of pro-inflammatory cytokines in addition to CARs,

Indexed as

Immunotherapy, AdoptiveAlpharetrovirusBrain NeoplasmsCell LineCell MovementCoculture TechniquesCytokinesGenetic VectorsGlioblastomaHumansKiller Cells, NaturalNFATC Transcription FactorsNF-kappa BCytokinesNFATC Transcription FactorsNF-kappa B“all-in-one” TRUCKalpharetroviral vectorschimeric antigen receptor (CAR)immunomodulatory cytokinesimmunotherapyNFκBNK cellstumor microenvironment

Identifiers

PMID34804035
PMCPMC8595471
OpenAlexW3211307309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.