Evidence map›Paper›PMID 34804016›Full record

ArticleFrontiers in immunology2021

The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease.

Masamitsu Kono, Denisa Nanushaj, Hideki Sakatani, Daichi Murakami, Masayoshi Hijiya, Tetsuya Kinoshita, Tatsuya Shiga, Fumie Kaneko, Keisuke Enomoto, Gen Sugita and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Masamitsu KonoDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Denisa NanushajDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Hideki SakataniDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Daichi MurakamiDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Masayoshi HijiyaDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Tetsuya KinoshitaDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Tatsuya ShigaDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Fumie KanekoDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Keisuke EnomotoDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Gen SugitaDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Masayasu MiyajimaDepartment of Ophthalmology, Wakayama Medical University, Wakayama, Japan.
Yuka OkadaDepartment of Ophthalmology, Wakayama Medical University, Wakayama, Japan.
Shizuya SaikaDepartment of Ophthalmology, Wakayama Medical University, Wakayama, Japan.
Muneki HotomiDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Wakayama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient receptor potential (TRP) channels, neuronal stimulations widely known to be associated with thermal responses, pain induction, and osmoregulation, have been shown in recent studies to have underlying mechanisms associated with inflammatory responses. The role of TRP channels on inflammatory milieu during bacterial infections has been widely demonstrated. It may vary among types of channels/pathogens, however, and it is not known how TRP channels function during pneumococcal infections.

Indexed as

AnimalsCoinfectionCytokinesDisease Models, AnimalHost-Pathogen InteractionsInflammation MediatorsInfluenza A Virus, H3N2 SubtypeMiceMice, Inbred C57BLMice, KnockoutNasal MucosaNeutrophilsOrthomyxoviridae InfectionsPhagocytosisPneumococcal InfectionsSignal TransductionCytokinesInflammation MediatorsTRPV1 protein, mouseTrpv4 protein, mouseTRPV Cation Channelsinfluenza virusmouse modelnasal colonizationpneumoniasepsisStreptococcus pneumoniae (pneumococcus)transient receptor potential (TRP)

Identifiers

PMID34804016
PMCPMC8595402
OpenAlexW3208736729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.