Evidence map›Paper›PMID 34804014›Full record

ArticleFrontiers in immunology2021

IL-4-Producing Vγ1

Leon Ullrich, Yvonne Lueder, Anna-Lena Juergens, Anneke Wilharm, Joana Barros-Martins, Anja Bubke, Abdi Demera, Koichi Ikuta, Gwendolyn Elena Patzer, Anika Janssen and 3 more

Open access · goldAbstract readVideo-Audio Media
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  10. The function of γδ T cells in humoral immune responses.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Leon UllrichInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Yvonne LuederInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Anna-Lena JuergensInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Anneke WilharmInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Joana Barros-MartinsInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Anja BubkeInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Abdi DemeraInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Koichi IkutaInstitute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Gwendolyn Elena PatzerInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Anika JanssenInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Inga SandrockInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Immo PrinzInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Francesca RampoldiInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Medizinische Hochschule Hannover · DEKyoto University · JPUniversity Medical Center Hamburg-Eppendorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mucosal immune system is the first line of defense against pathogens. Germinal centers (GCs) in the Peyer's patches (PPs) of the small intestine are constantly generated through stimulation of the microbiota. In this study, we investigated the role of γδ T cells in the GC reactions in PPs. Most γδ T cells in PPs localized in the GCs and expressed a TCR composed of Vγ1 and Vδ6 chains. By using mice with partial and total γδ T cell deficiencies, we found that Vγ1

Indexed as

AnimalsB-LymphocytesCell DifferentiationCell ProliferationCells, CulturedDisease Models, AnimalGerminal CenterImmunity, MucosalImmunoglobulin AImmunoglobulin Class SwitchingInterleukin-4Intestinal MucosaIntraepithelial LymphocytesLymphocyte ActivationLymphocyte DepletionMiceIl4 protein, mouseImmunoglobulin AInterleukin-4Receptors, Antigen, T-Cell, gamma-deltagerminal centerIgAIL-4Peyer’s patchesVγ1+ T cellsγδ T cells

Identifiers

PMID34804014
PMCPMC8600568
OpenAlexW3210048932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.