Evidence map›Paper›PMID 34804013›Full record

ArticleFrontiers in immunology2021

Genetic Analyses of Common Infections in the Avon Longitudinal Study of Parents and Children Cohort.

Amanda H W Chong, Ruth E Mitchell, Gibran Hemani, George Davey Smith, Robert H Yolken, Rebecca C Richmond, Lavinia Paternoster

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  3. Mendelian Randomization and Infection: Pitfalls and Promises.The Journal of infectious diseases · 2025
    Review
  4. Systematic Review of Mendelian Randomization Studies onInterdisciplinary perspectives on infectious diseases · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Causal associations betweenFrontiers in cellular and infection microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Amanda H W ChongMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Ruth E MitchellMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Gibran HemaniMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
George Davey SmithMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Robert H YolkenStanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Rebecca C RichmondMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Lavinia PaternosterMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
University of Bristol · GBJohns Hopkins University · US

Funding

Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_17228Medical Research Council MC_PC_19009Medical Research Council MC_QA137853Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/3Medical Research Council MC_UU_00011/4Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_00011/7Wellcome Trust 076467/Z/05/ZWellcome Trust 208806/Z/17/ZWellcome Trust 217065/Z/19/Z
6 · The paper itself

Abstract

The burden of infections on an individual and public health is profound. Many observational studies have shown a link between infections and the pathogenesis of disease; however a greater understanding of the role of host genetics is essential. Children from the longitudinal birth cohort, the Avon Longitudinal Study of Parents and Children, had 14 antibodies measured in plasma at age 7: Alpha-casein protein, beta-casein protein, cytomegalovirus, Epstein-Barr virus, feline herpes virus,

Indexed as

AdolescentAntibodies, BacterialAntibodies, ProtozoanAntibodies, ViralAntigens, ProtozoanBacteriaBacterial InfectionsCaseinsChildGenome-Wide Association StudyHLA AntigensHumansLongitudinal StudiesPolymorphism, Single NucleotideProtozoan ProteinsToxoplasmaAntibodies, BacterialAntibodies, ProtozoanAntibodies, ViralAntigens, ProtozoanCaseinsHLA AntigensProtozoan ProteinsSAG1 antigen, ToxoplasmaALSPACantibodygeneticsHLAinfection

Identifiers

PMID34804013
PMCPMC8599591
OpenAlexW3214404993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.