Evidence map›Paper›PMID 34804009›Full record

ArticleFrontiers in immunology2021

Splenic Transcriptional Responses in Severe Visceral Leishmaniasis: Impaired Leukocyte Chemotaxis and Cell Cycle Arrest.

Caroline Vilas Boas de Melo, Felipe Guimarães Torres, Micely D'El-Rei Hermida, Jonathan L M Fontes, Bianca Ramos Mesquita, Reginaldo Brito, Pablo Ivan P Ramos, Gabriel R Fernandes, Luiz Antônio Rodrigues Freitas, Ricardo Khouri and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Frontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Caroline Vilas Boas de MeloLaboratório de Patologia Estrutural e Molecular (LAPEM), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Felipe Guimarães TorresLaboratório de Enfermidades Infecciosas Transmitidas por Vetores (LEITV), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Micely D'El-Rei HermidaLaboratório de Patologia Estrutural e Molecular (LAPEM), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Jonathan L M FontesLaboratório de Patologia Estrutural e Molecular (LAPEM), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Bianca Ramos MesquitaLaboratório de Patologia Estrutural e Molecular (LAPEM), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Reginaldo BritoLaboratório de Patologia Estrutural e Molecular (LAPEM), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Pablo Ivan P RamosCentro de Integração de Dados e Conhecimentos para Saúde (CIDACS), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Gabriel R FernandesInformática de Biossistemas, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brazil.
Luiz Antônio Rodrigues FreitasLaboratório de Patologia Estrutural e Molecular (LAPEM), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Ricardo KhouriLaboratório de Enfermidades Infecciosas Transmitidas por Vetores (LEITV), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Carlos Henrique Nery CostaDepartamento de Medicina Comunitária, Instituto de Doenças Tropicais Natan Portella, Universidade Federal do Piauí, Teresina, Brazil.
Washington L C Dos-SantosLaboratório de Patologia Estrutural e Molecular (LAPEM), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Fundação Oswaldo Cruz · BRUniversidade Federal do Piauí · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Structural changes in the spleen have been reported in several infectious diseases. In visceral leishmaniasis (VL), a severe parasitic disease caused by

Indexed as

AnimalsCalcium-Binding ProteinsCell Cycle CheckpointsChemotaxis, LeukocyteCricetinaeCyclin-Dependent Kinase Inhibitor p16FemaleGene Expression ProfilingHumansHyperplasiaLeishmaniasis, VisceralLeukocytesMaleMembrane ProteinsMiddle AgedSpleenCalcium-Binding ProteinsCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16DLK1 protein, humanMembrane Proteinshamsterspleen disorganizationspleen pathologytranscriptomic (RNA-Seq)visceral leishmanaisiswhite pulp remodeling

Identifiers

PMID34804009
PMCPMC8602831
OpenAlexW3213646038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.