Evidence map›Paper›PMID 34803723›Full record

ReviewFrontiers in pharmacology2021

Potential Role for Combined Subtype-Selective Targeting of M

Mazen Tolaymat, Margaret H Sundel, Madeline Alizadeh, Guofeng Xie, Jean-Pierre Raufman

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mazen TolaymatDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD, United States.
Margaret H SundelDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, United States.
Madeline AlizadehDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD, United States.
Guofeng XieDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD, United States.
Jean-Pierre RaufmanDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD, United States.
University of Maryland, Baltimore · USVA Maryland Health Care System · US

Funding

Research Training in Gastroenterology and HepatologyT32DK067872 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI RAUFMAN, JEAN-PIERRE · 2005 to 2024
$7.2M
M3R, MMP1 and Colon Cancer DisseminationI01BX002129 · VA · BALTIMORE VA MEDICAL CENTER · PI RAUFMAN, JEAN-PIERRE · 2015 to 2018
–
Transcriptional Repression of MMP7 by FXR in Intestinal Epithelial CellsI01BX002777 · VA · BALTIMORE VA MEDICAL CENTER · PI XIE, GUOFENG · 2016 to 2020
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BLRD VA I01 BX002129BLRD VA I01 BX002777BLRD VA I01 BX004890NIDDK NIH HHS T32 DK067872
6 · The paper itself

Abstract

Despite structural similarity, the five subtypes comprising the cholinergic muscarinic family of G protein-coupled receptors regulate remarkably diverse biological functions. This mini review focuses on the closely related and commonly co-expressed M

Indexed as

cancergastrointestinal diseasegastrointestinal physiologyG protein-coupled receptorsliver diseasemuscarinic receptors

Identifiers

PMID34803723
PMCPMC8600121
OpenAlexW3209186362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.