Evidence map›Paper›PMID 34803709›Full record

ArticleFrontiers in pharmacology2021

Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder.

Anna M Gutridge, Soumen Chakraborty, Balazs R Varga, Elizabeth S Rhoda, Alexander R French, Arryn T Blaine, Quinten H Royer, Haoyue Cui, Jinling Yuan, Robert J Cassell and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Identification of 1,3,8-Triazaspiro[4.5]Decane-2,4-Dione Derivatives as a NovelThe Journal of pharmacology and experimental therapeutics · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Clinical Implications of Kratom (Current addiction reports · 2023
    Review
  10. Review
  11. Opioid signaling and design of analgesics.Progress in molecular biology and translational science · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Anna M GutridgeDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, United States.
Soumen ChakrabortyCenter for Clinical Pharmacology, University of Heath Sciences and Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, MO, United States.
Balazs R VargaCenter for Clinical Pharmacology, University of Heath Sciences and Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, MO, United States.
Elizabeth S RhodaDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, United States.
Alexander R FrenchDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, United States.
Arryn T BlaineDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, United States.
Quinten H RoyerDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, United States.
Haoyue CuiDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, United States.
Jinling YuanDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, United States.
Robert J CassellDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, United States.
Márk SzabóXiMo Hungary Ltd, Budapest, Hungary.
Susruta MajumdarCenter for Clinical Pharmacology, University of Heath Sciences and Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, MO, United States.
Richard M van RijnDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, United States.
Purdue University West Lafayette · USWashington University in St. Louis · US

Funding

G-protein-, beta-arrestin- and ERK-signaling in alcohol use- and anxiety-disordersR01AA025368 · NIAAA · PURDUE UNIVERSITY · PI CHESTER, JULIA ANN · 2017 to 2021
$1.7M
Pharmacological Probes based on mitragynine pseudoindoxylR33DA045884 · NIDA · ST. LOUIS COLLEGE OF PHARMACY · PI MAJUMDAR, SUSRUTA, SAMES, DALIBOR · 2020 to 2021
$792k
Analgesics targeting truncated 6transmembrane exon 11 variants of MOR-1 (6TM-E11)R21DA034106 · NIDA · SLOAN-KETTERING INST CAN RESEARCH · PI MAJUMDAR, SUSRUTA · 2012 to 2013
$443k
Opioidergic alkaloids from Mitragynia Speciosa (kratom) as novel treatment for alcohol use disorderR21AA026949 · NIAAA · PURDUE UNIVERSITY · PI VAN RIJN, RICHARD M. · 2018 to 2019
$421k
Development of G-protein biased delta opioid receptor agonist with analgesic potencyR03DA045897 · NIDA · PURDUE UNIVERSITY · PI VAN RIJN, RICHARD M. · 2018 to 2019
$149k
NIAAA NIH HHS R01 AA025368NIAAA NIH HHS R21 AA026949NIDA NIH HHS R03 DA045897NIDA NIH HHS R21 DA034106NIDA NIH HHS R33 DA045884
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alcohol use disorderbiased signalingdelta opioid receptorkratomnociceptionrewardseizures

Identifiers

PMID34803709
PMCPMC8596301
OpenAlexW3209074440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.