ReviewFrontiers in neural circuits2021
Challenges to the Vestibular System in Space: How the Brain Responds and Adapts to Microgravity.
Review in Frontiers in neural circuits, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Unravelling the Impact of Microgravity on Calcium Ion Signaling and Sensorium in Spaceflight.Life (Basel, Switzerland) · 2026Review
- Review
- Neurophysiological effects of partial gravity on bimanual control: a parabolic flight study.NPJ microgravity · 2026Article
- The effect of artificial gravity on the outcome of a two-week resistance vibration exercise programme: BRAVE study.Experimental physiology · 2026Article
- Brain displacement and nonlinear deformation following human spaceflight.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neural changes in microgravity: Investigating the effects of aerospace environments.IBRO neuroscience reports · 2025Review
- Article
- Modulation of vestibular function and receptor expression by experimental hypergravity in a rat model.Scientific reports · 2025Article
- The effect of vibrotactile feedback on performance, perception and trust when balancing in different analog g-levels.Experimental brain research · 2025Article
- Functional and Structural Changes in the Inner Ear and Cochlear Hair Cell Loss Induced by Hypergravity.International journal of molecular sciences · 2025Article
- From astronauts to stroke survivors: how the TheraSuit Method® can boost balance and recovery.Frontiers in neurology · 2025Article
- Stressors affect human motor timing during spaceflight.NPJ microgravity · 2024Article
- Formaldehyde initiates memory and motor impairments under weightlessness condition.NPJ microgravity · 2024Review
- Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA).Nature communications · 2024Article
- The effects of long-term exposure to microgravity and body orientation relative to gravity on perceived traveled distance.NPJ microgravity · 2024Article
- The ground reaction force pattern during walking under vestibular-demanding task with/without mastoid vibration: implication for future sensorimotor training in astronauts.Frontiers in physiology · 2024Article
- Cardiovascular responses to leg-press exercises during head-down tilt.Frontiers in sports and active living · 2024Article
- Reoptimization of single-joint motor patterns to non-Earth gravity torques induced by a robotic exoskeleton.iScience · 2023Article
- [Recent progress in vestibular prosthesis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
In the next century, flying civilians to space or humans to Mars will no longer be a subject of science fiction. The altered gravitational environment experienced during space flight, as well as that experienced following landing, results in impaired perceptual and motor performance-particularly in the first days of the new environmental challenge. Notably, the absence of gravity unloads the vestibular otolith organs such that they are no longer stimulated as they would be on earth. Understanding how the brain responds initially and then adapts to altered sensory input has important implications for understanding the inherent abilities as well as limitations of human performance. Space-based experiments have shown that altered gravity causes structural and functional changes at multiple stages of vestibular processing, spanning from the hair cells of its sensory organs to the Purkinje cells of the vestibular cerebellum. Furthermore, ground-based experiments have established the adaptive capacity of vestibular pathways and neural mechanism that likely underlie this adaptation. We review these studies and suggest that the brain likely uses two key strategies to adapt to changes in gravity: (i) the updating of a cerebellum-based internal model of the sensory consequences of gravity; and (ii) the re-weighting of extra-vestibular information as the vestibular system becomes less (i.e., entering microgravity) and then again more reliable (i.e., return to earth).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.