Evidence map›Paper›PMID 34803499›Full record

ArticleInternational journal of biological sciences2021

CD38 Deficiency Protects Mice from High Fat Diet-Induced Nonalcoholic Fatty Liver Disease through Activating NAD

Lin Xie, Ke Wen, Qian Li, Cong-Cong Huang, Jia-Le Zhao, Qi-Hang Zhao, Yun-Fei Xiao, Xiao-Hui Guan, Yi-Song Qian, Lu Gan and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

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  13. Journal of pharmaceutical analysis · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Lin XieNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine.
Ke WenNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine.
Qian LiNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine.
Cong-Cong HuangNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine.
Jia-Le ZhaoNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine.
Qi-Hang ZhaoNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine.
Yun-Fei XiaoNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine.
Xiao-Hui GuanNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine.
Yi-Song QianNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine.
Lu GanResearch Laboratory of Emergency Medicine, Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China.
Ling-Fang WangNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine.
Ke-Yu DengNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine.
Hong-Bo XinNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine.
Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in hepatocytes. CD38 was initially identified as a lymphocyte surface antigen and then has been found to exist in a variety of cell types. Our previous studies showed that CD38

Indexed as

ADP-ribosyl Cyclase 1AnimalsDiet, High-FatGene Expression RegulationHepatocytesLipid MetabolismMaleMembrane GlycoproteinsMiceMice, KnockoutNADNon-alcoholic Fatty Liver DiseaseOxidative StressSignal TransductionSirtuinsADP-ribosyl Cyclase 1Cd38 protein, mouseMembrane GlycoproteinsNADSirtuinsCD38lipid accumulationoxidative stressperoxisome proliferator-activated receptor αSirtuins

Identifiers

PMID34803499
PMCPMC8579443
OpenAlexW3208238109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.