Evidence map›Paper›PMID 34803491›Full record

ArticleInternational journal of biological sciences2021

Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice.

Ming Zhao, Yingyao Quan, Jianming Zeng, Xueying Lyu, Haitao Wang, Josh Haipeng Lei, Yangyang Feng, Jun Xu, Qiang Chen, Heng Sun and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Ming ZhaoCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Yingyao QuanCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Jianming ZengCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Xueying LyuCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Haitao WangCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Josh Haipeng LeiCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Yangyang FengCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Jun XuCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Qiang ChenCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Heng SunCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Xiaoling XuCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Ligong LuZhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University.
Chu-Xia DengCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China.
City University of Macau · MOUniversity of Macau · MOZhuhai People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholangiocarcinoma (CC), the most lethal type of liver cancer, remains very difficult to treat due to an incomplete understanding of the cancer initiation and progression mechanisms and no effective therapeutic drugs. Thus, identification of genomic drivers and delineation of the underlying mechanisms are urgently needed. Here, we conducted a genome-wide CRISPR-Cas9 screening in liver-specific Smad4/Pten knockout mice (

Indexed as

Tumor MicroenvironmentAnimalsAntibodiesAntineoplastic AgentsCD8-Positive T-LymphocytesCholangiocarcinomaCRISPR-Cas SystemsCullin ProteinsGene Expression RegulationGene Knockdown TechniquesLiverLiver NeoplasmsMiceMutationProgrammed Cell Death 1 ReceptorPTEN PhosphohydrolaseAntibodiesAntineoplastic AgentsCul3 protein, mouseCullin ProteinsPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorPTEN PhosphohydrolasePten protein, mouseSmad4 ProteinSmad4 protein, mouseSorafenibanti-PD1/PD-L1 therapyCholangiocarcinomaexhausted T cellsinflammatory cytokinestumor microenvironment

Identifiers

PMID34803491
PMCPMC8579464
OpenAlexW3208783157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.