ReviewInternational journal of biological sciences2021
Current Advancement on the Dynamic Mechanism of Gastroesophageal Reflux Disease.
Review in International journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Efficacy of Baclofen as Add-on Therapy for Refractory Gastroesophageal Reflux Disease: A Meta-analysis.Journal of clinical gastroenterology · 2025Pooled it
- Association between body mass index at different levels and risk of gastroesophageal reflux disease: a systematic review with dose-response meta-analysis.Frontiers in physiology · 2025Pooled it
- Pooled it
- Seeing beyond words: nanotechnology in hepatocellular carcinoma - a bibliometric study.Frontiers in oncology · 2024Pooled it
- Characterization of gastroesophageal reflux in patients during anesthesia induction: a high-resolution impedance manometry study.Die Anaesthesiologie · 2025Trial
- Evaluation of Aluminum and Magnesium Absorption Following the Oral Administration of an Antacid Suspension Containing Magaldrate in Healthy Women Under Fed Conditions.Advances in therapy · 2024Trial
- Effect of Fermented Soybean (FSB) Supplementation on Gastroesophageal Reflux Disease (GERD).Nutrients · 2024Trial
- Self-management of reflux symptoms after esophagectomy in China: A qualitative study.Asia-Pacific journal of oncology nursing · 2026Article
- Effects of Vonoprazan on Isolated Rat Lower Esophageal Sphincter and Ileum.Pharmaceuticals (Basel, Switzerland) · 2026Article
- A Cross-Sectional Dual-Site Analysis of the Gastric Antral and Duodenal Mucosa-Associated Microbiome Across Gastroesophageal Reflux Disease Phenotypes.Biomedicines · 2026Article
- Integrating ultrasound biomechanics and clinical assessments to examine breastfeeding function: novel insights into tongue mobility, milk transfer, and reflux symptoms.International breastfeeding journal · 2026Article
- Causal association between gastroesophageal reflux disease and anemia: Mendelian randomization analysis.Annals of medicine and surgery (2012) · 2026Article
- The global, regional, and national patterns of change in the burden of gastroesophageal reflux disease, 1990-2021: An analysis of the global burden of disease study 2021 and forecast to 2036.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2026Article
- Gastroesophageal Reflux Disease Incidence in Adolescents and Young Adults Aged 10-24 Years: Results from the Global Burden of Disease Study.Digestive diseases and sciences · 2026Article
- Impact of Inspiratory Muscle Training in Individuals with Gastroesophageal Reflux Disease: A Randomized Controlled Trial Protocol.Methods and protocols · 2026Article
- Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease?World journal of gastroenterology · 2026Article
- Impact of arm position and load on upper and lower esophageal sphincter pressures.Frontiers in physiology · 2026Article
- The Impact of GERD Symptoms and Endoscopic RE on Early Postoperative GERD After LSG.Obesity surgery · 2025Article
- Recent advances in machine learning for precision diagnosis and treatment of esophageal disorders.World journal of gastroenterology · 2025Review
- Physical Exercise as a Therapeutic Approach in Gastrointestinal Diseases.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastroesophageal reflux disease (GERD) is a common clinical disease associated with upper gastrointestinal motility disorders. Recently, with improvements in living standards and changes in lifestyle and dietary habits, the incidence of GERD has been increasing yearly. However, the mechanism of GERD has not been fully elucidated due to its complex pathogenesis, and this had led to unsatisfactory therapeutic outcomes. Currently, the occurrence and development of GERD involve multiple factors. Its pathogenesis is mainly thought to be related to factors, such as lower esophageal sphincter pressure, transient lower esophageal sphincter relaxation, crural diaphragmatic dysfunction, hiatus hernia, and impaired esophageal clearance. Therefore, explaining the pathogenesis of GERD more clearly and systematically, exploring potential and effective therapeutic targets, and choosing the best treatment methods have gradually become the focus of scholars' attention. Herein, we reviewed current advancements in the dynamic mechanism of GERD to better counsel patients on possible treatment options.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.