ReviewThe Saudi dental journal2021
Endodontic postoperative flare-up: An update.
Review in The Saudi dental journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07116252 (Effect of Sequential Versus Continous Chelation Protocols on Postoperative Endodontic Pain and Matrix Metalloproteinase-9 Levels), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Sequential Versus Continous Chelation Protocols on Postoperative Endodontic Pain and Matrix Metalloproteinase-9 Levels: A Randomized Clinical Study
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Factors Associated With Endodontic Flare-Ups: A Systematic Review and Meta-Analysis.International endodontic journal · 2026Pooled it
- Effect of Different Sodium Hypochlorite Concentrations on Post Endodontic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Clinical and experimental dental research · 2026Pooled it
- Pooled it
- Clinical and biochemical effects of cryotherapy protocols on mandibular premolars with symptomatic apical periodontitis: a randomized clinical trial.Clinical oral investigations · 2026Trial
- Does maintaining apical patency reduce early postoperative pain after root canal treatment? A randomized controlled trial in : asymptomatic vital single-rooted teeth.Clinical oral investigations · 2026Trial
- Comparison of the Efficacy of Dexamethasone and Methylprednisolone in Infiltration Injection for Postendodontic Pain in Patients with Necrotic Pulp: A Randomized Controlled Clinical Trial.Pain research & management · 2022Trial
- Investigation of Genetic Polymorphisms in Inducible Nitric Oxide Synthase and Suppressor of Cytokine Signaling Genes and Pain After Root Canal Treatment.Biochemical genetics · 2026Article
- Different final irrigation protocols on postoperative pain and swelling following single-visit non-surgical root canal treatment in necrotic mandibular first molars: a randomized controlled trial.The Saudi dental journal · 2026Article
- Postoperative Pain and Matrix Metalloproteinase-9 Pulpal Blood Level in Symptomatic Pulpitis of Mature Molars Treated with Biodentine and Portland Cement Full Pulpotomy: A Randomized Clinical Trial.Journal of clinical and experimental dentistry · 2026Review
- Cyotoxicity of Etidronate as an Endodontic Chelator Against Periodontal Ligament Fibroblast.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- A Retrospective Study of CBCT-Based Detection of Endodontic Failures and Periapical Lesions in a Romanian Cohort.Journal of clinical medicine · 2025Article
- Evaluating Dental Pain in Diverse Conditions: Findings From Short-Form McGill Pain Questionnaire Study.International dental journal · 2025Article
- Review
- Postoperative pain in patients following endodontic treatment by XP-endo Shaper files: A systematic review and meta-analysis.Journal of conservative dentistry and endodontics · 2024Article
- Article
- Management of Endodontic Flare-Up in the Presence of Periapical Radiolucency: Case Report and Overview.Cureus · 2023Article
- Article
- [Repair of perirradicular tissues in non-surgical endodontic treatment. A review].Revista cientifica odontologica (Universidad Cientifica del Sur)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endodontic treatment corresponds to a combined chemical and mechanical approach, followed by a three dimensional hermetic obturation, that eliminate the pulpal and periradiculare disease and boost healing and repair of periradiculare tissue. Despite the advances in the endodontic field, the inter-appointment flare up remains a true nightmare that encounters every dentist. This complication commences a few hours or days after root canal procedures and it is characterized by the development of pain and/or swelling, requiring an unscheduled appointment for emergency treatment. Different studies showed that flare-ups represent a multifactorial phenomenon including mechanical, chemical and microbial factors. In addition, a correlation was found between flare-up and age, gender, tooth type, presence of preoperative pain, tooth condition before treatment, irrigation techniques, number of visits as well as intracanal medication. Moreover, some medicine intake was proved to be efficient in controlling this postoperative pain. However, a clear procedure to avoid its occurrence is yet to be established. In this review, we summarize knowledge about the etiology of flare-up and its related factors. This could be effective in helping dentists to adapt some strategies to prevent it.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.