Evidence map›Paper›PMID 34803274›Full record

ArticleBioinformation2020

Anticancer effects and lysosomal acidification in A549 cells by Astaxanthin from Haematococcus lacustris.

K Ramamoorthy, Subramanian Raghunandhakumar, R S Anand, A Paramasivam, S Kamaraj, S Nagaraj, Devaraj Ezhilarasan, Thangavelu Lakshmi, Kamal Dua, Dinesh Kumar Chellappan and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Melanin pigments from sediment-associatedJournal of advanced pharmaceutical technology & research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

K RamamoorthyCentre for Advanced Studies in Botany, University of Madras (Guindy Campus), Chennai, India-600 025.
Subramanian RaghunandhakumarDepartment of Pharmacology, Saveetha Dental College, Saveetha University, Chennai, India.
R S AnandCentre for Biotechnology, Anna University, Chennai - 600 025.
A ParamasivamBiomedical Research Unit and Laboratory Animal Centre-Dental Research Cell, Saveetha Dental College, Saveetha University, Chennai, India.
S KamarajDepartment of Biotechnology, Periyar University (PG Extension Centre), Dharmapuri - 636701.
S NagarajCentre for Advanced Studies in Botany, University of Madras (Guindy Campus), Chennai, India-600 025.
Devaraj EzhilarasanDepartment of Pharmacology, Saveetha Dental College, Saveetha University, Chennai, India.
Thangavelu LakshmiDepartment of Pharmacology, Saveetha Dental College, Saveetha University, Chennai, India.
Kamal DuaDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
Dinesh Kumar ChellappanDepartment of Life sciences, School of Pharmacy, International Medical University, Bukit Jalil ,57000,Kualalumpur, Malaysia.
Ashokkumar VeeramuthuDepartment of Chemical Technology, Chulalongkorn University, Bangkok,Thailand.
University of Madras · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astaxanthin (AXN) is known to have health benefits by epidemiological studies. Therefore, it is of interest to assess the effect of AXN (derived from indigenous unicellular green alga Haematococcus lacustris) to modulate cell cycle arrest, lysosomal acidification and eventually apoptosis using in vitro in A549 lung cancer cells. Natural extracts of astaxanthin were obtained by standardized methods as reported earlier and characterized by standard HPLC and MS. Treatment of A549 cells with AXN (purified fraction) showed significant reduction in cell viability (about 50%) as compared to crude extract at 50µM concentration. Thus, we show the anticancer effects and lysosomal acidification in A549 cells by Astaxanthin from Haematococcus lacustris for further consideration. Together, our results demonstrated the anticancer potential of AXN from Haematococcus lacustris, which is found to be mediated via its ability to induce cell cycle arrest, lysosomal acidification and apoptotic induction.

Indexed as

A549 cellsApoptosisAstaxanthinHaematococcus lacustrisLysosomal acidification

Identifiers

PMID34803274
PMCPMC8573450
OpenAlexW3096436936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.