Evidence map›Paper›PMID 34803261›Full record

ArticleBioinformation2020

Molecular docking analysis of C-phycocyanin with VEGFR2.

Saira M Bannu, Dakshayani Lomada, Sravani Varala, Madhava C Reddy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. New Oxazolo[5,4-International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Saira M BannuDepartment of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa AP 516005, India.
Dakshayani LomadaDepartment of Genetics and Genomics, Yogi Vemana University, Kadapa, AP 516005, India.
Sravani VaralaDepartment of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa AP 516005, India.
Madhava C ReddyDepartment of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa AP 516005, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

C-phycocyanin (C-PC) produced from cyanobacterial species finds application in drug development. Therefore, it is of interest to document the molecular binding features of C-PC with the vascular endothelial growth factor receptor 2 (VEGFR2). C-PC showed H-bond interactions with residues on both sides of the Deusche Forschugsgemein-Schalt (DFG) loop (Asp1046-Phe1047-Gly1048). A hydrophobic association between the activation loop and the DFG residue (Gly1048) helps to inhibit the activity of VEGFR2 kinases. Thus, C-PC is reported as a potential angiogenesis inhibitor for VEGFR2 in combating cancer.

Indexed as

AngiogenesisCancer treatmentC-PhycocyaninMolecular dockingVEGFR2

Identifiers

PMID34803261
PMCPMC8573453

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.