Evidence map›Paper›PMID 34802467›Full record

ArticleBMC nutrition2021

Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial.

Siv K Bøhn, Mari C W Myhrstad, Magne Thoresen, Iris Erlund, Ann Kristin Vasstrand, Anne Marciuch, Monica H Carlsen, Nasser E Bastani, Knut Engedal, Kjell M Flekkøy and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00972972 (Effect of Bilberry), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00972972 early_phase1unknown statusnot on this map

Effect of Bilberry (European Blueberries) and Grape Polyphenols on Cognition and Blood Parameters in Normal, Aged Men With Subjective Memory Decline

TypeinterventionalSponsorUllevaal University HospitalRan2006 to 2009Enrolled61ConditionsMemory, Gene ExpressionArmsbilberry (European blueberries) and red grape juice, placebo juice
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Anti-Inflammatory Activity of Bilberry (Current issues in molecular biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Siv K BøhnDepartment of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, Ås, Norway. sivb@nmbu.no.ORCID http://orcid.org/0000-0002-1131-0456
Mari C W MyhrstadDepartment of Nutrition, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway.
Magne ThoresenDepartment of Biostatistics, Institute of Basic Medical Sciences, Oslo, Norway.
Iris ErlundDepartment of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland.
Ann Kristin VasstrandDepartment of Psychology, University of Oslo, Oslo, Norway.
Anne MarciuchDepartment of Psychology, University of Oslo, Oslo, Norway.
Monica H CarlsenDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Nasser E BastaniDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Knut EngedalDepartment of geriatric medicine, Oslo university hospital, Oslo, Norway.
Kjell M FlekkøyDepartment of Psychology, University of Oslo, Oslo, Norway.
Rune BlomhoffDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
University of Oslo · NOFinnish Institute for Health and Welfare · FINorwegian University of Life Sciences · NOOsloMet – Oslo Metropolitan University · NOOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew randomized clinical trials have explored the health effects of bilberries in humans. The aim was to test the effect of bilberry and red grape-juice consumption on visual memory, motor speed and dexterity as well as inflammatory and tissue damage biomarkers of plasma in aged men with subjective memory impairment.

methodsNine-week double-blind, placebo-controlled, dietary intervention study of aged men (n = 60, age ≥ 67 years) with subjective memory impairment randomized to consume a 50/50 mix of bilberry/red grape-juice or an iso-caloric placebo juice. A selection of Cambridge Cognition Test Battery (CANTAB), Grooved Pegboard tests and blood-sampling for biomarker analysis were performed before and after the intervention.

resultsCompared to placebo the selected memory and motor test scores were un-affected by the bilberry/red grape intervention. However, the plasma levels of tissue damage biomarkers decreased significantly more in the bilberry/red grape group. In particular lactate dehydrogenase (LDH) decreased from 362 U/L (median, baseline) to 346 U/L (median, post intervention) in the bilberry/red grape group. Also, several biomarkers of inflammation (EGF, IL6, IL9, IL10 and TNFα) decreased significantly more in the bilberry/red grape group. Furthermore, several plasma polyphenols; p-coumaric acid, hippuric acid, protocatechuic acid, 3HPAA and vanillic acid, increased significantly more in the bilberry/red grape group compared to placebo with the largest increase in p-coumaric acid with 116%; from 2.2 [1.0,5.5] to 4.7 [2.8,8.1] μM/L (median [95% CL]).

conclusionsThe results indicate that a nine-week bilberry/red grape juice intervention has no measurable effects on the selected memory scores in aged men experiencing memory problems but decreases the level of biomarkers of inflammation and tissue damage. Whether the dampening effects on inflammation and tissue damage biomarkers have relevance for neuroinflammatory brain pathology remains to be established.

trial registrationRegistration number ( ClinicalTrials.gov : NCT00972972 ), September 9, 2009.

Indexed as

Aged menBilberry; blueberry; blueberriesCytokinesGrapeInflammationMemory

Identifiers

PMID34802467
PMCPMC8607697
OpenAlexW3216392980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.